Serine peptidase inhibitor, Kunitz type 1
Intermolecular
Cysteine 101 and cysteine 657 of Suppressor of tumorigenicity 14 protein
Cysteine 77 and cysteine 657 of Suppressor of tumorigenicity 14 protein
Cysteine 101 and cysteine 641 of Suppressor of tumorigenicity 14 protein
Cysteine 77 and cysteine 641 of Suppressor of tumorigenicity 14 protein
Intramolecular
Cysteine 93 and cysteine 114
Cysteine 68 and cysteine 118
Cysteine 77 and cysteine 101
Cysteine 114 and cysteine 118
Cysteine 93 and cysteine 118
Cysteine 68 and cysteine 114
Cysteine 68 and cysteine 93
4isn B 283 A 58
A redox-regulated disulphide may form between cysteine 101 of Serine peptidase inhibitor, Kunitz type 1 and cysteine 657 of Suppressor of tumorigenicity 14 protein (283 and 58 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
4isn
Structure name
crystal structure of matriptase in complex with its inhibitor hai-1
Structure deposition date
2013-01-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide A name
Serine peptidase inhibitor, Kunitz type 1
Peptide B name
Suppressor of tumorigenicity 14 protein
Peptide A accession
H3BR01
Peptide B accession
Q9Y5Y6
Peptide A residue number
101
Peptide B residue number
657
Ligandability
Cysteine 101 of Serine peptidase inhibitor, Kunitz type 1
Cysteine 657 of Suppressor of tumorigenicity 14 protein
4isn B 259 A 58
A redox-regulated disulphide may form between cysteine 77 of Serine peptidase inhibitor, Kunitz type 1 and cysteine 657 of Suppressor of tumorigenicity 14 protein (259 and 58 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
4isn
Structure name
crystal structure of matriptase in complex with its inhibitor hai-1
Structure deposition date
2013-01-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
103
Minimum pKa ?
nan
% buried
nan
Peptide A name
Serine peptidase inhibitor, Kunitz type 1
Peptide B name
Suppressor of tumorigenicity 14 protein
Peptide A accession
H3BR01
Peptide B accession
Q9Y5Y6
Peptide A residue number
77
Peptide B residue number
657
Ligandability
Cysteine 77 of Serine peptidase inhibitor, Kunitz type 1
Cysteine 657 of Suppressor of tumorigenicity 14 protein
4isn B 283 A 42
A redox-regulated disulphide may form between cysteine 101 of Serine peptidase inhibitor, Kunitz type 1 and cysteine 641 of Suppressor of tumorigenicity 14 protein (283 and 42 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
4isn
Structure name
crystal structure of matriptase in complex with its inhibitor hai-1
Structure deposition date
2013-01-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide A name
Serine peptidase inhibitor, Kunitz type 1
Peptide B name
Suppressor of tumorigenicity 14 protein
Peptide A accession
H3BR01
Peptide B accession
Q9Y5Y6
Peptide A residue number
101
Peptide B residue number
641
Ligandability
Cysteine 101 of Serine peptidase inhibitor, Kunitz type 1
Cysteine 641 of Suppressor of tumorigenicity 14 protein
4isn B 259 A 42
A redox-regulated disulphide may form between cysteine 77 of Serine peptidase inhibitor, Kunitz type 1 and cysteine 641 of Suppressor of tumorigenicity 14 protein (259 and 42 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
4isn
Structure name
crystal structure of matriptase in complex with its inhibitor hai-1
Structure deposition date
2013-01-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
100
Minimum pKa ?
nan
% buried
nan
Peptide A name
Serine peptidase inhibitor, Kunitz type 1
Peptide B name
Suppressor of tumorigenicity 14 protein
Peptide A accession
H3BR01
Peptide B accession
Q9Y5Y6
Peptide A residue number
77
Peptide B residue number
641
Ligandability
Cysteine 77 of Serine peptidase inhibitor, Kunitz type 1
Cysteine 641 of Suppressor of tumorigenicity 14 protein
4isn B 275 B 296
A redox-regulated disulphide may form within Serine peptidase inhibitor, Kunitz type 1 between cysteines 93 and 114 (275 and 296 respectively in this structure).
Details
Redox score ?
87
PDB code
4isn
Structure name
crystal structure of matriptase in complex with its inhibitor hai-1
Structure deposition date
2013-01-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
H3BR01
Residue number A
93
Residue number B
114
Peptide name
Serine peptidase inhibitor, Kunitz type 1
Ligandability
Cysteine 93 of Serine peptidase inhibitor, Kunitz type 1
Cysteine 114 of Serine peptidase inhibitor, Kunitz type 1
4isn B 250 B 300
A redox-regulated disulphide may form within Serine peptidase inhibitor, Kunitz type 1 between cysteines 68 and 118 (250 and 300 respectively in this structure).
Details
Redox score ?
86
PDB code
4isn
Structure name
crystal structure of matriptase in complex with its inhibitor hai-1
Structure deposition date
2013-01-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
H3BR01
Residue number A
68
Residue number B
118
Peptide name
Serine peptidase inhibitor, Kunitz type 1
Ligandability
Cysteine 68 of Serine peptidase inhibitor, Kunitz type 1
Cysteine 118 of Serine peptidase inhibitor, Kunitz type 1
4isn B 259 B 283
A redox-regulated disulphide may form within Serine peptidase inhibitor, Kunitz type 1 between cysteines 77 and 101 (259 and 283 respectively in this structure).
Details
Redox score ?
80
PDB code
4isn
Structure name
crystal structure of matriptase in complex with its inhibitor hai-1
Structure deposition date
2013-01-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
H3BR01
Residue number A
77
Residue number B
101
Peptide name
Serine peptidase inhibitor, Kunitz type 1
Ligandability
Cysteine 77 of Serine peptidase inhibitor, Kunitz type 1
Cysteine 101 of Serine peptidase inhibitor, Kunitz type 1
4isn B 296 B 300
A redox-regulated disulphide may form within Serine peptidase inhibitor, Kunitz type 1 between cysteines 114 and 118 (296 and 300 respectively in this structure).
Details
Redox score ?
70
PDB code
4isn
Structure name
crystal structure of matriptase in complex with its inhibitor hai-1
Structure deposition date
2013-01-16
Thiol separation (Å)
5
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
H3BR01
Residue number A
114
Residue number B
118
Peptide name
Serine peptidase inhibitor, Kunitz type 1
Ligandability
Cysteine 114 of Serine peptidase inhibitor, Kunitz type 1
Cysteine 118 of Serine peptidase inhibitor, Kunitz type 1
4isn B 275 B 300
A redox-regulated disulphide may form within Serine peptidase inhibitor, Kunitz type 1 between cysteines 93 and 118 (275 and 300 respectively in this structure).
Details
Redox score ?
66
PDB code
4isn
Structure name
crystal structure of matriptase in complex with its inhibitor hai-1
Structure deposition date
2013-01-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
H3BR01
Residue number A
93
Residue number B
118
Peptide name
Serine peptidase inhibitor, Kunitz type 1
Ligandability
Cysteine 93 of Serine peptidase inhibitor, Kunitz type 1
Cysteine 118 of Serine peptidase inhibitor, Kunitz type 1
4isn B 250 B 296
A redox-regulated disulphide may form within Serine peptidase inhibitor, Kunitz type 1 between cysteines 68 and 114 (250 and 296 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
4isn
Structure name
crystal structure of matriptase in complex with its inhibitor hai-1
Structure deposition date
2013-01-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
H3BR01
Residue number A
68
Residue number B
114
Peptide name
Serine peptidase inhibitor, Kunitz type 1
Ligandability
Cysteine 68 of Serine peptidase inhibitor, Kunitz type 1
Cysteine 114 of Serine peptidase inhibitor, Kunitz type 1
4isn B 250 B 275
A redox-regulated disulphide may form within Serine peptidase inhibitor, Kunitz type 1 between cysteines 68 and 93 (250 and 275 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
4isn
Structure name
crystal structure of matriptase in complex with its inhibitor hai-1
Structure deposition date
2013-01-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
H3BR01
Residue number A
68
Residue number B
93
Peptide name
Serine peptidase inhibitor, Kunitz type 1
Ligandability
Cysteine 68 of Serine peptidase inhibitor, Kunitz type 1
Cysteine 93 of Serine peptidase inhibitor, Kunitz type 1
If this tool was useful for finding a disulphide, please cite: