ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Galectin-3-binding protein

Intramolecular
Cysteine 153 and cysteine 170
Cysteine 201 and cysteine 226
A redox-regulated disulphide may form within Galectin-3-binding protein between cysteines 153 and 170.

Details

Redox score ?
85
PDB code
6gfc
Structure name
structure of the btb/poz domain of human 90k
Structure deposition date
2018-04-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
H9FUB4
Residue number A
153
Residue number B
170
Peptide name
Galectin-3-binding protein

Ligandability

Cysteine 153 of Galectin-3-binding protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 170 of Galectin-3-binding protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Galectin-3-binding protein between cysteines 201 and 226.

Details

Redox score ?
83
PDB code
6gfc
Structure name
structure of the btb/poz domain of human 90k
Structure deposition date
2018-04-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
H9FUB4
Residue number A
201
Residue number B
226
Peptide name
Galectin-3-binding protein

Ligandability

Cysteine 201 of Galectin-3-binding protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 226 of Galectin-3-binding protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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