ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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MHC class II antigen

Intramolecular
Cysteine 110 and cysteine 166
Cysteine 10 and cysteine 72
A redox-regulated disulphide may form within MHC class II antigen between cysteines 110 and 166 (115 and 171 respectively in this structure).

Details

Redox score ?
79
PDB code
3wex
Structure name
crystal structure of hla-dp5 in complex with cry j 1-derived peptide (residues 214-222)
Structure deposition date
2013-07-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
I2FL84
Residue number A
110
Residue number B
166
Peptide name
MHC class II antigen

Ligandability

Cysteine 110 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 166 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class II antigen between cysteines 10 and 72 (15 and 77 respectively in this structure).

Details

Redox score ?
79
PDB code
3wex
Structure name
crystal structure of hla-dp5 in complex with cry j 1-derived peptide (residues 214-222)
Structure deposition date
2013-07-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
I2FL84
Residue number A
10
Residue number B
72
Peptide name
MHC class II antigen

Ligandability

Cysteine 10 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 72 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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