a tool for identifying drug-targetable redox-active disulphides

Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

Intermolecular

Cysteine 368 and cysteine 368

A redox-regulated disulphide may form between two units of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 at cysteines 368 and 368. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

36

PDB code

Structure name

crystal structure of pig samhd1

Structure deposition date

2017-09-30

Thiol separation (Å)

10

Half-sphere exposure sum ?

73

Minimum pK_a ?

8

% buried

100

Peptide A name

Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

Peptide B name

Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

Peptide A accession

Peptide B accession

Peptide A residue number

368

Peptide B residue number

368

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: