NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Intermolecular
Cysteine 152 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial and cysteine 166
Cysteine 155 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial and cysteine 166
Intramolecular
Cysteine 136 and cysteine 166
Cysteine 72 and cysteine 166
Cysteine 71 and cysteine 166
Cysteine 72 and cysteine 136
Cysteine 71 and cysteine 136
Cysteine 71 and cysteine 72
7v2k B 152 C 166
A redox-regulated disulphide may form between cysteine 152 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial and cysteine 166 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7v2k
Structure name
deactive state complex i from dq-nadh dataset
Structure deposition date
2021-08-09
Thiol separation (Å)
8
Half-sphere exposure sum ?
94
Minimum pKa ?
7
% buried
100
Peptide A name
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Peptide B name
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Peptide A accession
A0A287BDC0
Peptide B accession
I3LK43
Peptide A residue number
152
Peptide B residue number
166
Ligandability
Cysteine 152 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Cysteine 166 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
7v33 B 155 C 166
A redox-regulated disulphide may form between cysteine 155 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial and cysteine 166 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7v33
Structure name
active state complex i from rotenone-nadh dataset
Structure deposition date
2021-08-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
98
Minimum pKa ?
10
% buried
100
Peptide A name
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Peptide B name
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Peptide A accession
A0A287BDC0
Peptide B accession
I3LK43
Peptide A residue number
155
Peptide B residue number
166
Ligandability
Cysteine 155 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Cysteine 166 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
7w1o C 136 C 166
A redox-regulated disulphide may form within NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial between cysteines 136 and 166. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
7w1o
Structure name
deactive state ci from q10-nadh dataset, subclass 1
Structure deposition date
2021-11-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
99
Minimum pKa ?
10
% buried
100
Peptide accession
I3LK43
Residue number A
136
Residue number B
166
Peptide name
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Ligandability
Cysteine 136 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Cysteine 166 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
7v2d C 72 C 166
A redox-regulated disulphide may form within NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial between cysteines 72 and 166. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7v2d
Structure name
deactive state complex i from q10 dataset
Structure deposition date
2021-08-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
95
Minimum pKa ?
10
% buried
100
Peptide accession
I3LK43
Residue number A
72
Residue number B
166
Peptide name
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Ligandability
Cysteine 72 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Cysteine 166 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
7vzw C 71 C 166
A redox-regulated disulphide may form within NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial between cysteines 71 and 166. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7vzw
Structure name
active state ci from q10 dataset, subclass 2
Structure deposition date
2021-11-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
96
Minimum pKa ?
10
% buried
100
Peptide accession
I3LK43
Residue number A
71
Residue number B
166
Peptide name
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Ligandability
Cysteine 71 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Cysteine 166 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
7vy8 C 72 C 136
A redox-regulated disulphide may form within NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial between cysteines 72 and 136. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7vy8
Structure name
matrix arm of active state ci from q10-nadh dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
90
Minimum pKa ?
13
% buried
100
Peptide accession
I3LK43
Residue number A
72
Residue number B
136
Peptide name
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Ligandability
Cysteine 72 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Cysteine 136 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
7vy8 C 71 C 136
A redox-regulated disulphide may form within NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial between cysteines 71 and 136. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7vy8
Structure name
matrix arm of active state ci from q10-nadh dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
90
Minimum pKa ?
13
% buried
100
Peptide accession
I3LK43
Residue number A
71
Residue number B
136
Peptide name
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Ligandability
Cysteine 71 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Cysteine 136 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
7vyf C 71 C 72
A redox-regulated disulphide may form within NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial between cysteines 71 and 72. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7vyf
Structure name
matrix arm of active state ci from rotenone dataset
Structure deposition date
2021-11-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
90
Minimum pKa ?
14
% buried
100
Peptide accession
I3LK43
Residue number A
71
Residue number B
72
Peptide name
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Ligandability
Cysteine 71 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Cysteine 72 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
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