a tool for identifying drug-targetable redox-active disulphides

39S ribosomal protein L19, mitochondrial

Intramolecular

Cysteine 148 and cysteine 174

A redox-regulated disulphide may form within 39S ribosomal protein L19, mitochondrial between cysteines 148 and 174 (137 and 163 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

36

PDB code

Structure name

39s large subunit of the porcine mitochondrial ribosome

Structure deposition date

2013-11-08

Thiol separation (Å)

8

Half-sphere exposure sum ?

76

Minimum pK_a ?

12

% buried

92

Peptide accession

Residue number A

148

Residue number B

174

Peptide name

39S ribosomal protein L19, mitochondrial

Ligandability

Cysteine 148 of 39S ribosomal protein L19, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of 39S ribosomal protein L19, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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