ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Mitochondrial ribosomal protein L32

Intramolecular
Cysteine 142 and cysteine 145
Cysteine 129 and cysteine 132
Cysteine 129 and cysteine 142
Cysteine 129 and cysteine 145
Cysteine 132 and cysteine 142
Cysteine 132 and cysteine 145
A redox-regulated disulphide may form within Mitochondrial ribosomal protein L32 between cysteines 142 and 145 (123 and 126 respectively in this structure).

Details

Redox score ?
92
PDB code
4ce4
Structure name
39s large subunit of the porcine mitochondrial ribosome
Structure deposition date
2013-11-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
6
% buried
3
Peptide accession
I3LTC4
Residue number A
142
Residue number B
145
Peptide name
Mitochondrial ribosomal protein L32

Ligandability

Cysteine 142 of Mitochondrial ribosomal protein L32

Cysteine 145 of Mitochondrial ribosomal protein L32

A redox-regulated disulphide may form within Mitochondrial ribosomal protein L32 between cysteines 129 and 132 (110 and 113 respectively in this structure).

Details

Redox score ?
90
PDB code
4v19
Structure name
structure of the large subunit of the mammalian mitoribosome, part 1 of 2
Structure deposition date
2014-09-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
6
% buried
10
Peptide accession
I3LTC4
Residue number A
129
Residue number B
132
Peptide name
Mitochondrial ribosomal protein L32

Ligandability

Cysteine 129 of Mitochondrial ribosomal protein L32

Cysteine 132 of Mitochondrial ribosomal protein L32

A redox-regulated disulphide may form within Mitochondrial ribosomal protein L32 between cysteines 129 and 142 (110 and 123 respectively in this structure).

Details

Redox score ?
89
PDB code
4ce4
Structure name
39s large subunit of the porcine mitochondrial ribosome
Structure deposition date
2013-11-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
6
% buried
7
Peptide accession
I3LTC4
Residue number A
129
Residue number B
142
Peptide name
Mitochondrial ribosomal protein L32

Ligandability

Cysteine 129 of Mitochondrial ribosomal protein L32

Cysteine 142 of Mitochondrial ribosomal protein L32

A redox-regulated disulphide may form within Mitochondrial ribosomal protein L32 between cysteines 129 and 145 (110 and 126 respectively in this structure).

Details

Redox score ?
89
PDB code
4ce4
Structure name
39s large subunit of the porcine mitochondrial ribosome
Structure deposition date
2013-11-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
7
% buried
4
Peptide accession
I3LTC4
Residue number A
129
Residue number B
145
Peptide name
Mitochondrial ribosomal protein L32

Ligandability

Cysteine 129 of Mitochondrial ribosomal protein L32

Cysteine 145 of Mitochondrial ribosomal protein L32

A redox-regulated disulphide may form within Mitochondrial ribosomal protein L32 between cysteines 132 and 142 (113 and 123 respectively in this structure).

Details

Redox score ?
88
PDB code
4ce4
Structure name
39s large subunit of the porcine mitochondrial ribosome
Structure deposition date
2013-11-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
6
% buried
4
Peptide accession
I3LTC4
Residue number A
132
Residue number B
142
Peptide name
Mitochondrial ribosomal protein L32

Ligandability

Cysteine 132 of Mitochondrial ribosomal protein L32

Cysteine 142 of Mitochondrial ribosomal protein L32

A redox-regulated disulphide may form within Mitochondrial ribosomal protein L32 between cysteines 132 and 145 (113 and 126 respectively in this structure).

Details

Redox score ?
84
PDB code
4ce4
Structure name
39s large subunit of the porcine mitochondrial ribosome
Structure deposition date
2013-11-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
I3LTC4
Residue number A
132
Residue number B
145
Peptide name
Mitochondrial ribosomal protein L32

Ligandability

Cysteine 132 of Mitochondrial ribosomal protein L32

Cysteine 145 of Mitochondrial ribosomal protein L32

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