a tool for identifying drug-targetable redox-active disulphides

Actin gamma 1

Intramolecular

Cysteine 217 and cysteine 257

A redox-regulated disulphide may form within Actin gamma 1 between cysteines 217 and 257.

Details

Redox score ?

69

PDB code

Structure name

human cytoplasmic dynein-1 bound to dynactin and an n-terminal construct of bicd2

Structure deposition date

2017-05-05

Thiol separation (Å)

4

Half-sphere exposure sum ?

78

Minimum pK_a ?

8

% buried

100

Peptide accession

Residue number A

217

Residue number B

257

Peptide name

Actin gamma 1

Ligandability

Cysteine 217 of Actin gamma 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 257 of Actin gamma 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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