ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transient receptor potential cation channel subfamily V member 1

Intermolecular
Cysteine 623 and cysteine 623
Intramolecular
Cysteine 388 and cysteine 392
A redox-regulated disulphide may form between two units of Transient receptor potential cation channel subfamily V member 1 at cysteines 623 and 623.

Details

Redox score ?
82
PDB code
7lqy
Structure name
structure of squirrel trpv1 in apo state
Structure deposition date
2021-02-15
Thiol separation (Å)
5
Half-sphere exposure sum ?
54
Minimum pKa ?
3
% buried
66
Peptide A name
Transient receptor potential cation channel subfamily V member 1
Peptide B name
Transient receptor potential cation channel subfamily V member 1
Peptide A accession
I3LZN5
Peptide B accession
I3LZN5
Peptide A residue number
623
Peptide B residue number
623

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily V member 1 between cysteines 388 and 392. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7lr0
Structure name
structure of squirrel trpv1 in complex with capsaicin
Structure deposition date
2021-02-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
40
Peptide accession
I3LZN5
Residue number A
388
Residue number B
392
Peptide name
Transient receptor potential cation channel subfamily V member 1

Ligandability

Cysteine 388 of Transient receptor potential cation channel subfamily V member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 392 of Transient receptor potential cation channel subfamily V member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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