ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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KIR3DL1

Intramolecular
Cysteine 244 and cysteine 293
Cysteine 144 and cysteine 195
Cysteine 49 and cysteine 95
A redox-regulated disulphide may form within KIR3DL1 between cysteines 244 and 293 (223 and 272 respectively in this structure).

Details

Redox score ?
81
PDB code
7k81
Structure name
kir3dl1*005 in complex with hla-a*24:02 presenting the rypltfgw peptide
Structure deposition date
2020-09-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
I6LEL9
Residue number A
244
Residue number B
293
Peptide name
KIR3DL1

Ligandability

Cysteine 244 of KIR3DL1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 293 of KIR3DL1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within KIR3DL1 between cysteines 144 and 195 (123 and 174 respectively in this structure).

Details

Redox score ?
81
PDB code
7k81
Structure name
kir3dl1*005 in complex with hla-a*24:02 presenting the rypltfgw peptide
Structure deposition date
2020-09-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
I6LEL9
Residue number A
144
Residue number B
195
Peptide name
KIR3DL1

Ligandability

Cysteine 144 of KIR3DL1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 of KIR3DL1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within KIR3DL1 between cysteines 49 and 95 (28 and 74 respectively in this structure).

Details

Redox score ?
80
PDB code
7k81
Structure name
kir3dl1*005 in complex with hla-a*24:02 presenting the rypltfgw peptide
Structure deposition date
2020-09-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
I6LEL9
Residue number A
49
Residue number B
95
Peptide name
KIR3DL1

Ligandability

Cysteine 49 of KIR3DL1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 95 of KIR3DL1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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