a tool for identifying drug-targetable redox-active disulphides

Allergen Can f 4

Intramolecular

Cysteine 78 and cysteine 170

A redox-regulated disulphide may form within Allergen Can f 4 between cysteines 78 and 170 (62 and 154 respectively in this structure).

Details

Redox score ?

88

PDB code

Structure name

crystal structure of a dog lipocalin allergen

Structure deposition date

2014-01-10

Thiol separation (Å)

2

Half-sphere exposure sum ?

46

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

78

Residue number B

170

Peptide name

Allergen Can f 4

Ligandability

Cysteine 78 of Allergen Can f 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 170 of Allergen Can f 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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