T-cell receptor, sp3.4 alpha chain
Intermolecular
Cysteine 161 and cysteine 171 of TRB protein
Cysteine 161 and cysteine 168 of T cell receptor beta constant 1
Cysteine 161 and cysteine 176 of Human nkt tcr beta chain
Intramolecular
Cysteine 23 and cysteine 89
Cysteine 136 and cysteine 186
Cysteine 136 and cysteine 89
Cysteine 23 and cysteine 136
5nht A 158 B 171
A redox-regulated disulphide may form between cysteine 161 of T-cell receptor, sp3.4 alpha chain and cysteine 171 of TRB protein (158 and 171 respectively in this structure).
Details
Redox score ?
79
PDB code
5nht
Structure name
human 199
Structure deposition date
2017-03-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide A name
T-cell receptor, sp3
Peptide B name
TRB protein
Peptide A accession
K7N5N2
Peptide B accession
A0A0C4ZKA8
Peptide A residue number
161
Peptide B residue number
171
Ligandability
Cysteine 161 of T-cell receptor, sp3.4 alpha chain
Cysteine 171 of TRB protein
Cysteine 171 in protein B could not be asigned to a Uniprot residue.
4mnq D 159 E 168
A redox-regulated disulphide may form between cysteine 161 of T-cell receptor, sp3.4 alpha chain and cysteine 168 of T cell receptor beta constant 1 (159 and 168 respectively in this structure).
Details
Redox score ?
78
PDB code
4mnq
Structure name
tcr-peptide specificity overrides affinity enhancing tcr-mhc interactions
Structure deposition date
2013-09-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide A name
T-cell receptor, sp3
Peptide B name
T cell receptor beta constant 1
Peptide A accession
K7N5M9
Peptide B accession
P01850
Peptide A residue number
161
Peptide B residue number
168
Ligandability
Cysteine 161 of T-cell receptor, sp3.4 alpha chain
Cysteine 168 of T cell receptor beta constant 1
Cysteine 168 in protein B could not be asigned to a Uniprot residue.
7n4k D 174 E 180
A redox-regulated disulphide may form between cysteine 161 of T-cell receptor, sp3.4 alpha chain and cysteine 176 of Human nkt tcr beta chain (174 and 180 respectively in this structure).
Details
Redox score ?
74
PDB code
7n4k
Structure name
6218 tcr in complex with h2-db pa 224
Structure deposition date
2021-06-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
74
Minimum pKa ?
7
% buried
94
Peptide A name
T-cell receptor, sp3
Peptide B name
Human nkt tcr beta chain
Peptide A accession
K7N5N2
Peptide B accession
K7N5M4
Peptide A residue number
161
Peptide B residue number
176
Ligandability
Cysteine 161 of T-cell receptor, sp3.4 alpha chain
Cysteine 176 of Human nkt tcr beta chain
3pqy D 23 D 104
A redox-regulated disulphide may form within T-cell receptor, sp3.4 alpha chain between cysteines 23 and 89 (23 and 104 respectively in this structure).
Details
Redox score ?
82
PDB code
3pqy
Structure name
crystal structure of 6218 tcr in complex with the h2db-pa224
Structure deposition date
2010-11-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
K7N5N2
Residue number A
23
Residue number B
89
Peptide name
T-cell receptor, sp3
Ligandability
Cysteine 23 of T-cell receptor, sp3.4 alpha chain
Cysteine 89 of T-cell receptor, sp3.4 alpha chain
4mnq D 134 D 184
A redox-regulated disulphide may form within T-cell receptor, sp3.4 alpha chain between cysteines 136 and 186 (134 and 184 respectively in this structure).
Details
Redox score ?
82
PDB code
4mnq
Structure name
tcr-peptide specificity overrides affinity enhancing tcr-mhc interactions
Structure deposition date
2013-09-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
K7N5M9
Residue number A
136
Residue number B
186
Peptide name
T-cell receptor, sp3
Ligandability
Cysteine 136 of T-cell receptor, sp3.4 alpha chain
Cysteine 186 of T-cell receptor, sp3.4 alpha chain
6q3s D 23 D 90
A redox-regulated disulphide may form within T-cell receptor, sp3.4 alpha chain between cysteines 136 and 89 (23 and 90 respectively in this structure).
Details
Redox score ?
80
PDB code
6q3s
Structure name
engineered human hla_a2 mhc class i molecule in complex with tcr and sv9 peptide
Structure deposition date
2018-12-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
K7N5N2
Residue number A
136
Residue number B
89
Peptide name
T-cell receptor, sp3
Ligandability
Cysteine 136 of T-cell receptor, sp3.4 alpha chain
Cysteine 89 of T-cell receptor, sp3.4 alpha chain
5wkh I 23 I 100
A redox-regulated disulphide may form within T-cell receptor, sp3.4 alpha chain between cysteines 23 and 136 (23 and 100 respectively in this structure).
Details
Redox score ?
nan
PDB code
5wkh
Structure name
d30 tcr in complex with hla-a*11:01-gts3
Structure deposition date
2017-07-25
Thiol separation (Å)
3
Half-sphere exposure sum ?
84
Minimum pKa ?
8
% buried
86
Peptide accession
K7N5N2
Residue number A
23
Residue number B
136
Peptide name
T-cell receptor, sp3
Ligandability
Cysteine 23 of T-cell receptor, sp3.4 alpha chain
Cysteine 136 of T-cell receptor, sp3.4 alpha chain
Uncertain whether structure cysteine 23 has been assigned to correct residue.
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