ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Dipeptidyl peptidase 4

Intramolecular
Cysteine 367 and cysteine 376
Cysteine 426 and cysteine 429
Cysteine 436 and cysteine 454
Cysteine 631 and cysteine 744
Cysteine 310 and cysteine 321
A redox-regulated disulphide may form within Dipeptidyl peptidase 4 between cysteines 367 and 376 (380 and 389 respectively in this structure).

Details

Redox score ?
86
PDB code
6l8q
Structure name
complex structure of bat cd26 and mers-rbd
Structure deposition date
2019-11-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
L5LQ33
Residue number A
367
Residue number B
376
Peptide name
Dipeptidyl peptidase 4

Ligandability

Cysteine 367 of Dipeptidyl peptidase 4

Cysteine 376 of Dipeptidyl peptidase 4

A redox-regulated disulphide may form within Dipeptidyl peptidase 4 between cysteines 426 and 429 (439 and 442 respectively in this structure).

Details

Redox score ?
86
PDB code
6l8q
Structure name
complex structure of bat cd26 and mers-rbd
Structure deposition date
2019-11-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
L5LQ33
Residue number A
426
Residue number B
429
Peptide name
Dipeptidyl peptidase 4

Ligandability

Cysteine 426 of Dipeptidyl peptidase 4

Cysteine 429 of Dipeptidyl peptidase 4

A redox-regulated disulphide may form within Dipeptidyl peptidase 4 between cysteines 436 and 454 (449 and 467 respectively in this structure).

Details

Redox score ?
84
PDB code
6l8q
Structure name
complex structure of bat cd26 and mers-rbd
Structure deposition date
2019-11-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
L5LQ33
Residue number A
436
Residue number B
454
Peptide name
Dipeptidyl peptidase 4

Ligandability

Cysteine 436 of Dipeptidyl peptidase 4

Cysteine 454 of Dipeptidyl peptidase 4

A redox-regulated disulphide may form within Dipeptidyl peptidase 4 between cysteines 631 and 744 (644 and 757 respectively in this structure).

Details

Redox score ?
81
PDB code
6l8q
Structure name
complex structure of bat cd26 and mers-rbd
Structure deposition date
2019-11-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
L5LQ33
Residue number A
631
Residue number B
744
Peptide name
Dipeptidyl peptidase 4

Ligandability

Cysteine 631 of Dipeptidyl peptidase 4

Cysteine 744 of Dipeptidyl peptidase 4

A redox-regulated disulphide may form within Dipeptidyl peptidase 4 between cysteines 310 and 321 (323 and 334 respectively in this structure).

Details

Redox score ?
80
PDB code
6l8q
Structure name
complex structure of bat cd26 and mers-rbd
Structure deposition date
2019-11-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
L5LQ33
Residue number A
310
Residue number B
321
Peptide name
Dipeptidyl peptidase 4

Ligandability

Cysteine 310 of Dipeptidyl peptidase 4

Cysteine 321 of Dipeptidyl peptidase 4

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