ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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WD repeat-containing protein 20

Intramolecular
Cysteine 405 and cysteine 554
Cysteine 576 and cysteine 582
Cysteine 103 and cysteine 180
Cysteine 293 and cysteine 295
Cysteine 180 and cysteine 263
A redox-regulated disulphide may form within WD repeat-containing protein 20 between cysteines 405 and 554 (379 and 528 respectively in this structure).

Details

Redox score ?
76
PDB code
6jlq
Structure name
crystal structure of human usp46-wdr48-wdr20 complex
Structure deposition date
2019-03-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
7
% buried
89
Peptide accession
L8I535
Residue number A
405
Residue number B
554
Peptide name
WD repeat-containing protein 20

Ligandability

Cysteine 405 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 554 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 20 between cysteines 576 and 582 (550 and 556 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6jlq
Structure name
crystal structure of human usp46-wdr48-wdr20 complex
Structure deposition date
2019-03-06
Thiol separation (Å)
6
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
100
Peptide accession
L8I535
Residue number A
576
Residue number B
582
Peptide name
WD repeat-containing protein 20

Ligandability

Cysteine 576 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 582 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 20 between cysteines 103 and 180 (103 and 154 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6jlq
Structure name
crystal structure of human usp46-wdr48-wdr20 complex
Structure deposition date
2019-03-06
Thiol separation (Å)
6
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
100
Peptide accession
L8I535
Residue number A
103
Residue number B
180
Peptide name
WD repeat-containing protein 20

Ligandability

Cysteine 103 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 20 between cysteines 293 and 295 (267 and 269 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6jlq
Structure name
crystal structure of human usp46-wdr48-wdr20 complex
Structure deposition date
2019-03-06
Thiol separation (Å)
7
Half-sphere exposure sum ?
87
Minimum pKa ?
13
% buried
100
Peptide accession
L8I535
Residue number A
293
Residue number B
295
Peptide name
WD repeat-containing protein 20

Ligandability

Cysteine 293 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 295 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 20 between cysteines 180 and 263 (154 and 237 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
6jlq
Structure name
crystal structure of human usp46-wdr48-wdr20 complex
Structure deposition date
2019-03-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
95
Minimum pKa ?
12
% buried
100
Peptide accession
L8I535
Residue number A
180
Residue number B
263
Peptide name
WD repeat-containing protein 20

Ligandability

Cysteine 180 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 263 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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