ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Lactoperoxidase

Intramolecular
Cysteine 671 and cysteine 696
Cysteine 132 and cysteine 145
Cysteine 250 and cysteine 274
Cysteine 246 and cysteine 256
Cysteine 123 and cysteine 284
Cysteine 573 and cysteine 630
Cysteine 354 and cysteine 365
Cysteine 246 and cysteine 274
Cysteine 256 and cysteine 274
Cysteine 246 and cysteine 250
Cysteine 250 and cysteine 256
A redox-regulated disulphide may form within Lactoperoxidase between cysteines 671 and 696 (554 and 579 respectively in this structure).

Details

Redox score ?
86
PDB code
6l5g
Structure name
crystal structure of yak lactoperoxidase with disordered heme moiety at 2
Structure deposition date
2019-10-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
L8ICE9
Residue number A
671
Residue number B
696
Peptide name
Lactoperoxidase

Ligandability

Cysteine 671 of Lactoperoxidase

Cysteine 696 of Lactoperoxidase

A redox-regulated disulphide may form within Lactoperoxidase between cysteines 132 and 145 (15 and 28 respectively in this structure).

Details

Redox score ?
86
PDB code
7c73
Structure name
crystal structure of yak lactoperoxidase using data obtained from crystals soaked in mgcl2 at 2
Structure deposition date
2020-05-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
L8ICE9
Residue number A
132
Residue number B
145
Peptide name
Lactoperoxidase

Ligandability

Cysteine 132 of Lactoperoxidase

Cysteine 145 of Lactoperoxidase

A redox-regulated disulphide may form within Lactoperoxidase between cysteines 250 and 274 (133 and 157 respectively in this structure).

Details

Redox score ?
85
PDB code
7c75
Structure name
crystal structure of yak lactoperoxidase with partially coordinated na ion in the distal heme cavity
Structure deposition date
2020-05-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
L8ICE9
Residue number A
250
Residue number B
274
Peptide name
Lactoperoxidase

Ligandability

Cysteine 250 of Lactoperoxidase

Cysteine 274 of Lactoperoxidase

A redox-regulated disulphide may form within Lactoperoxidase between cysteines 246 and 256 (129 and 139 respectively in this structure).

Details

Redox score ?
84
PDB code
7c73
Structure name
crystal structure of yak lactoperoxidase using data obtained from crystals soaked in mgcl2 at 2
Structure deposition date
2020-05-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
L8ICE9
Residue number A
246
Residue number B
256
Peptide name
Lactoperoxidase

Ligandability

Cysteine 246 of Lactoperoxidase

Cysteine 256 of Lactoperoxidase

A redox-regulated disulphide may form within Lactoperoxidase between cysteines 123 and 284 (6 and 167 respectively in this structure).

Details

Redox score ?
83
PDB code
6lqw
Structure name
crystal structure of a dimeric yak lactoperoxidase at 2
Structure deposition date
2020-01-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
L8ICE9
Residue number A
123
Residue number B
284
Peptide name
Lactoperoxidase

Ligandability

Cysteine 123 of Lactoperoxidase

Cysteine 284 of Lactoperoxidase

A redox-regulated disulphide may form within Lactoperoxidase between cysteines 573 and 630 (456 and 513 respectively in this structure).

Details

Redox score ?
81
PDB code
6ky7
Structure name
crystal structure of yak lactoperoxidase at 2
Structure deposition date
2019-09-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
L8ICE9
Residue number A
573
Residue number B
630
Peptide name
Lactoperoxidase

Ligandability

Cysteine 573 of Lactoperoxidase

Cysteine 630 of Lactoperoxidase

A redox-regulated disulphide may form within Lactoperoxidase between cysteines 354 and 365 (237 and 248 respectively in this structure).

Details

Redox score ?
81
PDB code
7c74
Structure name
crystal structure of yak lactoperoxidase using data obtained from crystals soaked in cacl2 at 2
Structure deposition date
2020-05-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
L8ICE9
Residue number A
354
Residue number B
365
Peptide name
Lactoperoxidase

Ligandability

Cysteine 354 of Lactoperoxidase

Cysteine 365 of Lactoperoxidase

A redox-regulated disulphide may form within Lactoperoxidase between cysteines 246 and 274 (129 and 157 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
6ky7
Structure name
crystal structure of yak lactoperoxidase at 2
Structure deposition date
2019-09-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
L8ICE9
Residue number A
246
Residue number B
274
Peptide name
Lactoperoxidase

Ligandability

Cysteine 246 of Lactoperoxidase

Cysteine 274 of Lactoperoxidase

A redox-regulated disulphide may form within Lactoperoxidase between cysteines 256 and 274 (139 and 157 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
6ky7
Structure name
crystal structure of yak lactoperoxidase at 2
Structure deposition date
2019-09-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
L8ICE9
Residue number A
256
Residue number B
274
Peptide name
Lactoperoxidase

Ligandability

Cysteine 256 of Lactoperoxidase

Cysteine 274 of Lactoperoxidase

A redox-regulated disulphide may form within Lactoperoxidase between cysteines 246 and 250 (129 and 133 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
6lqw
Structure name
crystal structure of a dimeric yak lactoperoxidase at 2
Structure deposition date
2020-01-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
L8ICE9
Residue number A
246
Residue number B
250
Peptide name
Lactoperoxidase

Ligandability

Cysteine 246 of Lactoperoxidase

Cysteine 250 of Lactoperoxidase

A redox-regulated disulphide may form within Lactoperoxidase between cysteines 250 and 256 (133 and 139 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
6lqw
Structure name
crystal structure of a dimeric yak lactoperoxidase at 2
Structure deposition date
2020-01-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
L8ICE9
Residue number A
250
Residue number B
256
Peptide name
Lactoperoxidase

Ligandability

Cysteine 250 of Lactoperoxidase

Cysteine 256 of Lactoperoxidase

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