ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dipeptidyl peptidase 9

Intramolecular
Cysteine 205 and cysteine 270
Cysteine 458 and cysteine 463
A redox-regulated disulphide may form within Dipeptidyl peptidase 9 between cysteines 205 and 270 (193 and 258 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7crw
Structure name
cryo-em structure of rnlrp1-rdpp9 complex
Structure deposition date
2020-08-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
78
Peptide accession
M0R781
Residue number A
205
Residue number B
270
Peptide name
Dipeptidyl peptidase 9

Ligandability

Cysteine 205 of Dipeptidyl peptidase 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 270 of Dipeptidyl peptidase 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dipeptidyl peptidase 9 between cysteines 458 and 463 (446 and 451 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
7crw
Structure name
cryo-em structure of rnlrp1-rdpp9 complex
Structure deposition date
2020-08-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
83
Peptide accession
M0R781
Residue number A
458
Residue number B
463
Peptide name
Dipeptidyl peptidase 9

Ligandability

Cysteine 458 of Dipeptidyl peptidase 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 463 of Dipeptidyl peptidase 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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