ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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AH receptor-interacting protein

Intramolecular
Cysteine 238 and cysteine 254
Cysteine 121 and cysteine 122 L
Cysteine 238 and cysteine 240
A redox-regulated disulphide may form within AH receptor-interacting protein between cysteines 238 and 254.

Details

Redox score ?
77
PDB code
8h77
Structure name
hsp90-ahr-p23-xap2 complex
Structure deposition date
2022-10-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
8
% buried
74
Peptide accession
O08915
Residue number A
238
Residue number B
254
Peptide name
AH receptor-interacting protein

Ligandability

Cysteine 238 of AH receptor-interacting protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 254 of AH receptor-interacting protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within AH receptor-interacting protein between cysteines 121 and 122. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
2lkn
Structure name
solution structure of the ppiase domain of human aryl-hydrocarbon receptor-interacting protein (aip)
Structure deposition date
2011-10-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
28
Minimum pKa ?
9
% buried
0
Peptide accession
O00170
Residue number A
121
Residue number B
122
Peptide name
AH receptor-interacting protein

Ligandability

Cysteine 121 of AH receptor-interacting protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 122 of AH receptor-interacting protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within AH receptor-interacting protein between cysteines 238 and 240. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
4aif
Structure name
aip tpr domain in complex with human hsp90 peptide
Structure deposition date
2012-02-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
90
Peptide accession
O00170
Residue number A
238
Residue number B
240
Peptide name
AH receptor-interacting protein

Ligandability

Cysteine 238 of AH receptor-interacting protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 240 of AH receptor-interacting protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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