ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Syntaxin-binding protein 3

Intramolecular
Cysteine 48 and cysteine 49
Cysteine 114 and cysteine 133
Cysteine 498 and cysteine 501 L
Cysteine 126 and cysteine 133
A redox-regulated disulphide may form within Syntaxin-binding protein 3 between cysteines 48 and 49.

Details

Redox score ?
61
PDB code
3puk
Structure name
re-refinement of the crystal structure of munc18-3 and syntaxin4 n- peptide complex
Structure deposition date
2010-12-05
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
12
% buried
76
Peptide accession
Q60770
Residue number A
48
Residue number B
49
Peptide name
Syntaxin-binding protein 3

Ligandability

Cysteine 48 of Syntaxin-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 49 of Syntaxin-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Syntaxin-binding protein 3 between cysteines 114 and 133. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
3puk
Structure name
re-refinement of the crystal structure of munc18-3 and syntaxin4 n- peptide complex
Structure deposition date
2010-12-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
78
Peptide accession
Q60770
Residue number A
114
Residue number B
133
Peptide name
Syntaxin-binding protein 3

Ligandability

Cysteine 114 of Syntaxin-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of Syntaxin-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Syntaxin-binding protein 3 between cysteines 498 and 501. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
3puk
Structure name
re-refinement of the crystal structure of munc18-3 and syntaxin4 n- peptide complex
Structure deposition date
2010-12-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
20
Peptide accession
Q60770
Residue number A
498
Residue number B
501
Peptide name
Syntaxin-binding protein 3

Ligandability

Cysteine 498 of Syntaxin-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 501 of Syntaxin-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Syntaxin-binding protein 3 between cysteines 126 and 133. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
3puk
Structure name
re-refinement of the crystal structure of munc18-3 and syntaxin4 n- peptide complex
Structure deposition date
2010-12-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
59
Peptide accession
Q60770
Residue number A
126
Residue number B
133
Peptide name
Syntaxin-binding protein 3

Ligandability

Cysteine 126 of Syntaxin-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of Syntaxin-binding protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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