ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ras-related protein Rab-27B

Intramolecular
Cysteine 123 and cysteine 218
Cysteine 123 and cysteine 188
A redox-regulated disulphide may form within Ras-related protein Rab-27B between cysteines 123 and 218 (123 and 188 respectively in this structure).

Details

Redox score ?
91
PDB code
2iez
Structure name
crystal structure of mouse rab27b bound to gdp in monoclinic space group
Structure deposition date
2006-09-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99P58
Residue number A
123
Residue number B
218
Peptide name
Ras-related protein Rab-27B

Ligandability

Cysteine 123 of Ras-related protein Rab-27B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 218 of Ras-related protein Rab-27B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ras-related protein Rab-27B between cysteines 123 and 188.

Details

Redox score ?
88
PDB code
2f7s
Structure name
the crystal structure of human rab27b bound to gdp
Structure deposition date
2005-12-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
34
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00194
Residue number A
123
Residue number B
188
Peptide name
Ras-related protein Rab-27B

Ligandability

Cysteine 123 of Ras-related protein Rab-27B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 188 of Ras-related protein Rab-27B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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