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a tool for identifying drug-targetable redox-active disulphides

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Tumor necrosis factor receptor superfamily member 10A

Intramolecular
Cysteine 207 and cysteine 221
Cysteine 148 and cysteine 164
Cysteine 170 and cysteine 188
Cysteine 211 and cysteine 229
Cysteine 132 and cysteine 145
Cysteine 167 and cysteine 180
Cysteine 190 and cysteine 204
Cysteine 148 and cysteine 167
Cysteine 148 and cysteine 180
Cysteine 190 and cysteine 207
More...
Cysteine 132 and cysteine 148
Cysteine 164 and cysteine 167
Cysteine 132 and cysteine 164
Cysteine 188 and cysteine 190
Cysteine 190 and cysteine 221
Cysteine 180 and cysteine 188
Cysteine 170 and cysteine 180
Cysteine 164 and cysteine 180
Cysteine 188 and cysteine 204
Cysteine 145 and cysteine 164
Cysteine 204 and cysteine 207
Cysteine 170 and cysteine 204
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 207 and 221.

Details

Redox score ?
89
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
207
Residue number B
221
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 207 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 221 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 148 and 164.

Details

Redox score ?
88
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
148
Residue number B
164
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 148 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 164 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 170 and 188.

Details

Redox score ?
88
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
170
Residue number B
188
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 170 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 188 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 211 and 229.

Details

Redox score ?
88
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
211
Residue number B
229
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 211 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 229 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 132 and 145.

Details

Redox score ?
87
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
132
Residue number B
145
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 132 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 167 and 180.

Details

Redox score ?
87
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
167
Residue number B
180
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 167 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 190 and 204.

Details

Redox score ?
83
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
190
Residue number B
204
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 190 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 204 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 148 and 167. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
148
Residue number B
167
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 148 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 167 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 148 and 180. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
148
Residue number B
180
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 148 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 190 and 207. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
190
Residue number B
207
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 190 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 207 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 132 and 148. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
132
Residue number B
148
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 132 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 148 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 164 and 167. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
164
Residue number B
167
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 164 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 167 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 132 and 164. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
132
Residue number B
164
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 132 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 164 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 188 and 190. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
188
Residue number B
190
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 188 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 190 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 190 and 221. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
190
Residue number B
221
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 190 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 221 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 180 and 188. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
180
Residue number B
188
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 180 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 188 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 170 and 180. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
170
Residue number B
180
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 170 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 164 and 180. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
164
Residue number B
180
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 164 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 188 and 204. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
188
Residue number B
204
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 188 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 204 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 145 and 164. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
145
Residue number B
164
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 145 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 164 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 204 and 207. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
204
Residue number B
207
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 204 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 207 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10A between cysteines 170 and 204. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
5cir
Structure name
crystal structure of death receptor 4 (dr4; tnffrsf10a) bound to trail (tnfsf10)
Structure deposition date
2015-07-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00220
Residue number A
170
Residue number B
204
Peptide name
Tumor necrosis factor receptor superfamily member 10A

Ligandability

Cysteine 170 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 204 of Tumor necrosis factor receptor superfamily member 10A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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