ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Metabotropic glutamate receptor 8

Intramolecular
Cysteine 424 and cysteine 431
Cysteine 369 and cysteine 384
Cysteine 64 and cysteine 106
A redox-regulated disulphide may form within Metabotropic glutamate receptor 8 between cysteines 424 and 431.

Details

Redox score ?
88
PDB code
6bt5
Structure name
human mglu8 receptor complexed with l-ap4
Structure deposition date
2017-12-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00222
Residue number A
424
Residue number B
431
Peptide name
Metabotropic glutamate receptor 8

Ligandability

Cysteine 424 of Metabotropic glutamate receptor 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 431 of Metabotropic glutamate receptor 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 8 between cysteines 369 and 384.

Details

Redox score ?
87
PDB code
6e5v
Structure name
human mglu8 receptor amino terminal domain in complex with (s)-3,4- dicarboxyphenylglycine (dcpg)
Structure deposition date
2018-07-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00222
Residue number A
369
Residue number B
384
Peptide name
Metabotropic glutamate receptor 8

Ligandability

Cysteine 369 of Metabotropic glutamate receptor 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 384 of Metabotropic glutamate receptor 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Metabotropic glutamate receptor 8 between cysteines 64 and 106.

Details

Redox score ?
83
PDB code
6bsz
Structure name
human mglu8 receptor complexed with glutamate
Structure deposition date
2017-12-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00222
Residue number A
64
Residue number B
106
Peptide name
Metabotropic glutamate receptor 8

Ligandability

Cysteine 64 of Metabotropic glutamate receptor 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of Metabotropic glutamate receptor 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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