ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cortistatin

Intermolecular
Cysteine 180 of Mas-related G-protein coupled receptor member X2 and cysteine 93
Cysteine 168 of Mas-related G-protein coupled receptor member X2 and cysteine 93
A redox-regulated disulphide may form between cysteine 180 of Mas-related G-protein coupled receptor member X2 and cysteine 93 of Cortistatin (180 and 22 respectively in this structure).

Details

Redox score ?
73
PDB code
7vv4
Structure name
cryo-em structure of pseudoallergen receptor mrgprx2 complex with linear cortistatin-14, local
Structure deposition date
2021-11-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
nan
Peptide A name
Mas-related G-protein coupled receptor member X2
Peptide B name
Cortistatin
Peptide A accession
Q96LB1
Peptide B accession
O00230
Peptide A residue number
180
Peptide B residue number
93

Ligandability

Cysteine 180 of Mas-related G-protein coupled receptor member X2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Cortistatin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 168 of Mas-related G-protein coupled receptor member X2 and cysteine 93 of Cortistatin (168 and 22 respectively in this structure).

Details

Redox score ?
63
PDB code
7vv4
Structure name
cryo-em structure of pseudoallergen receptor mrgprx2 complex with linear cortistatin-14, local
Structure deposition date
2021-11-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
57
Minimum pKa ?
9
% buried
nan
Peptide A name
Mas-related G-protein coupled receptor member X2
Peptide B name
Cortistatin
Peptide A accession
Q96LB1
Peptide B accession
O00230
Peptide A residue number
168
Peptide B residue number
93

Ligandability

Cysteine 168 of Mas-related G-protein coupled receptor member X2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Cortistatin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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