ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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26S proteasome non-ATPase regulatory subunit 12

Intramolecular
Cysteine 108 and cysteine 109
Cysteine 74 and cysteine 108
A redox-regulated disulphide may form within 26S proteasome non-ATPase regulatory subunit 12 between cysteines 108 and 109. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
5ln3
Structure name
the human 26s proteasome at 6
Structure deposition date
2016-08-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
78
Peptide accession
O00232
Residue number A
108
Residue number B
109
Peptide name
26S proteasome non-ATPase regulatory subunit 12

Ligandability

Cysteine 108 of 26S proteasome non-ATPase regulatory subunit 12

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of 26S proteasome non-ATPase regulatory subunit 12

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 26S proteasome non-ATPase regulatory subunit 12 between cysteines 74 and 108. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
5l4k
Structure name
the human 26s proteasome lid
Structure deposition date
2016-05-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
73
Peptide accession
O00232
Residue number A
74
Residue number B
108
Peptide name
26S proteasome non-ATPase regulatory subunit 12

Ligandability

Cysteine 74 of 26S proteasome non-ATPase regulatory subunit 12

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of 26S proteasome non-ATPase regulatory subunit 12

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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