ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Bone morphogenetic protein receptor type-1B

Intramolecular
Cysteine 34 and cysteine 38
Cysteine 81 and cysteine 95
Cysteine 32 and cysteine 53
Cysteine 47 and cysteine 71
Cysteine 96 and cysteine 102
Cysteine 34 and cysteine 47
Cysteine 32 and cysteine 71
Cysteine 53 and cysteine 102
Cysteine 32 and cysteine 47
Cysteine 38 and cysteine 47
More...
Cysteine 53 and cysteine 96
Cysteine 34 and cysteine 71
Cysteine 53 and cysteine 71
Cysteine 32 and cysteine 102
Cysteine 47 and cysteine 53
Cysteine 414 and cysteine 462
Cysteine 32 and cysteine 96
Cysteine 38 and cysteine 71
Cysteine 32 and cysteine 34
Cysteine 95 and cysteine 96
Cysteine 32 and cysteine 38
Cysteine 53 and cysteine 95
Cysteine 34 and cysteine 53
Cysteine 81 and cysteine 96
Cysteine 32 and cysteine 95
Cysteine 95 and cysteine 102
Cysteine 346 and cysteine 347
Cysteine 53 and cysteine 81
Cysteine 71 and cysteine 102
Cysteine 71 and cysteine 96
A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 34 and 38 (21 and 25 respectively in this structure).

Details

Redox score ?
89
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
34
Residue number B
38
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 34 of Bone morphogenetic protein receptor type-1B

Cysteine 38 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 81 and 95 (68 and 82 respectively in this structure).

Details

Redox score ?
84
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
81
Residue number B
95
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 81 of Bone morphogenetic protein receptor type-1B

Cysteine 95 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 32 and 53 (19 and 40 respectively in this structure).

Details

Redox score ?
82
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
32
Residue number B
53
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 32 of Bone morphogenetic protein receptor type-1B

Cysteine 53 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 47 and 71 (34 and 58 respectively in this structure).

Details

Redox score ?
81
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
47
Residue number B
71
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 47 of Bone morphogenetic protein receptor type-1B

Cysteine 71 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 96 and 102 (83 and 89 respectively in this structure).

Details

Redox score ?
78
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
96
Residue number B
102
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 96 of Bone morphogenetic protein receptor type-1B

Cysteine 102 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 34 and 47 (21 and 34 respectively in this structure).

Details

Redox score ?
75
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
34
Residue number B
47
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 34 of Bone morphogenetic protein receptor type-1B

Cysteine 47 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 32 and 71 (19 and 58 respectively in this structure).

Details

Redox score ?
73
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
32
Residue number B
71
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 32 of Bone morphogenetic protein receptor type-1B

Cysteine 71 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 53 and 102 (40 and 89 respectively in this structure).

Details

Redox score ?
69
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
53
Residue number B
102
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 53 of Bone morphogenetic protein receptor type-1B

Cysteine 102 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 32 and 47 (19 and 34 respectively in this structure).

Details

Redox score ?
68
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
32
Residue number B
47
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 32 of Bone morphogenetic protein receptor type-1B

Cysteine 47 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 38 and 47 (25 and 34 respectively in this structure).

Details

Redox score ?
68
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
38
Residue number B
47
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 38 of Bone morphogenetic protein receptor type-1B

Cysteine 47 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 53 and 96 (40 and 83 respectively in this structure).

Details

Redox score ?
64
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
53
Residue number B
96
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 53 of Bone morphogenetic protein receptor type-1B

Cysteine 96 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 34 and 71 (21 and 58 respectively in this structure).

Details

Redox score ?
61
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
34
Residue number B
71
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 34 of Bone morphogenetic protein receptor type-1B

Cysteine 71 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 53 and 71 (40 and 58 respectively in this structure).

Details

Redox score ?
60
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
53
Residue number B
71
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 53 of Bone morphogenetic protein receptor type-1B

Cysteine 71 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 32 and 102 (19 and 89 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
32
Residue number B
102
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 32 of Bone morphogenetic protein receptor type-1B

Cysteine 102 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 47 and 53 (34 and 40 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
47
Residue number B
53
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 47 of Bone morphogenetic protein receptor type-1B

Cysteine 53 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 414 and 462. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
3mdy
Structure name
crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1b (bmpr1b) in complex with fkbp12 and ldn- 193189
Structure deposition date
2010-03-31
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
56
Peptide accession
O00238
Residue number A
414
Residue number B
462
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 414 of Bone morphogenetic protein receptor type-1B

Cysteine 462 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 32 and 96 (19 and 83 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
32
Residue number B
96
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 32 of Bone morphogenetic protein receptor type-1B

Cysteine 96 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 38 and 71 (25 and 58 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
38
Residue number B
71
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 38 of Bone morphogenetic protein receptor type-1B

Cysteine 71 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 32 and 34 (19 and 21 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
32
Residue number B
34
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 32 of Bone morphogenetic protein receptor type-1B

Cysteine 34 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 95 and 96 (82 and 83 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
95
Residue number B
96
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 95 of Bone morphogenetic protein receptor type-1B

Cysteine 96 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 32 and 38 (19 and 25 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
32
Residue number B
38
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 32 of Bone morphogenetic protein receptor type-1B

Cysteine 38 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 53 and 95 (40 and 82 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
53
Residue number B
95
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 53 of Bone morphogenetic protein receptor type-1B

Cysteine 95 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 34 and 53 (21 and 40 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
34
Residue number B
53
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 34 of Bone morphogenetic protein receptor type-1B

Cysteine 53 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 81 and 96 (68 and 83 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
81
Residue number B
96
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 81 of Bone morphogenetic protein receptor type-1B

Cysteine 96 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 32 and 95 (19 and 82 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
32
Residue number B
95
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 32 of Bone morphogenetic protein receptor type-1B

Cysteine 95 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 95 and 102 (82 and 89 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
95
Residue number B
102
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 95 of Bone morphogenetic protein receptor type-1B

Cysteine 102 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 346 and 347. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
3mdy
Structure name
crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1b (bmpr1b) in complex with fkbp12 and ldn- 193189
Structure deposition date
2010-03-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
87
Minimum pKa ?
11
% buried
100
Peptide accession
O00238
Residue number A
346
Residue number B
347
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 346 of Bone morphogenetic protein receptor type-1B

Cysteine 347 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 53 and 81 (40 and 68 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
53
Residue number B
81
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 53 of Bone morphogenetic protein receptor type-1B

Cysteine 81 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 71 and 102 (58 and 89 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
71
Residue number B
102
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 71 of Bone morphogenetic protein receptor type-1B

Cysteine 102 of Bone morphogenetic protein receptor type-1B

A redox-regulated disulphide may form within Bone morphogenetic protein receptor type-1B between cysteines 71 and 96 (58 and 83 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
3evs
Structure name
crystal structure of the gdf-5:bmp receptor ib complex
Structure deposition date
2008-10-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P36898
Residue number A
71
Residue number B
96
Peptide name
Bone morphogenetic protein receptor type-1B

Ligandability

Cysteine 71 of Bone morphogenetic protein receptor type-1B

Cysteine 96 of Bone morphogenetic protein receptor type-1B

If this tool was useful for finding a disulphide, please cite: