ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Guided entry of tail-anchored proteins factor 1

Intermolecular
Cysteine 157 and cysteine 275 of Guided entry of tail-anchored proteins factor CAMLG
Cysteine 162 and cysteine 275 of Guided entry of tail-anchored proteins factor CAMLG
Intramolecular
Cysteine 157 and cysteine 162
Cysteine 21 and cysteine 162
A redox-regulated disulphide may form between cysteine 157 of Guided entry of tail-anchored proteins factor 1 and cysteine 275 of Guided entry of tail-anchored proteins factor CAMLG. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
6so5
Structure name
homo sapiens wrb/caml heterotetramer in complex with a trc40 dimer
Structure deposition date
2019-08-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
18
Peptide A name
Guided entry of tail-anchored proteins factor 1
Peptide B name
Guided entry of tail-anchored proteins factor CAMLG
Peptide A accession
O00258
Peptide B accession
P49069
Peptide A residue number
157
Peptide B residue number
275

Ligandability

Cysteine 157 of Guided entry of tail-anchored proteins factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 275 of Guided entry of tail-anchored proteins factor CAMLG

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 162 of Guided entry of tail-anchored proteins factor 1 and cysteine 275 of Guided entry of tail-anchored proteins factor CAMLG. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6so5
Structure name
homo sapiens wrb/caml heterotetramer in complex with a trc40 dimer
Structure deposition date
2019-08-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
9
% buried
52
Peptide A name
Guided entry of tail-anchored proteins factor 1
Peptide B name
Guided entry of tail-anchored proteins factor CAMLG
Peptide A accession
O00258
Peptide B accession
P49069
Peptide A residue number
162
Peptide B residue number
275

Ligandability

Cysteine 162 of Guided entry of tail-anchored proteins factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 275 of Guided entry of tail-anchored proteins factor CAMLG

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guided entry of tail-anchored proteins factor 1 between cysteines 157 and 162. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6so5
Structure name
homo sapiens wrb/caml heterotetramer in complex with a trc40 dimer
Structure deposition date
2019-08-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
48
Peptide accession
O00258
Residue number A
157
Residue number B
162
Peptide name
Guided entry of tail-anchored proteins factor 1

Ligandability

Cysteine 157 of Guided entry of tail-anchored proteins factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 162 of Guided entry of tail-anchored proteins factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guided entry of tail-anchored proteins factor 1 between cysteines 21 and 162. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6so5
Structure name
homo sapiens wrb/caml heterotetramer in complex with a trc40 dimer
Structure deposition date
2019-08-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
54
Peptide accession
O00258
Residue number A
21
Residue number B
162
Peptide name
Guided entry of tail-anchored proteins factor 1

Ligandability

Cysteine 21 of Guided entry of tail-anchored proteins factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 162 of Guided entry of tail-anchored proteins factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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