a tool for identifying drug-targetable redox-active disulphides

Transcription elongation factor SPT5

Intramolecular

Cysteine 626 and cysteine 638 L

A redox-regulated disulphide may form within Transcription elongation factor SPT5 between cysteines 626 and 638 (109 and 121 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

43

PDB code

Structure name

4th kow domain of human hspt5

Structure deposition date

2017-10-16

Thiol separation (Å)

9

Half-sphere exposure sum ?

65

Minimum pK_a ?

9

% buried

33

Peptide accession

Residue number A

626

Residue number B

638

Peptide name

Transcription elongation factor SPT5

Ligandability

Cysteine 626 of Transcription elongation factor SPT5

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 638 of Transcription elongation factor SPT5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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