ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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NEDD4-like E3 ubiquitin-protein ligase WWP2

Intramolecular
Cysteine 750 and cysteine 802
Cysteine 588 and cysteine 838
A redox-regulated disulphide may form within NEDD4-like E3 ubiquitin-protein ligase WWP2 between cysteines 750 and 802.

Details

Redox score ?
66
PDB code
6j1z
Structure name
wwp2 semi-open conformation
Structure deposition date
2018-12-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
9
% buried
100
Peptide accession
O00308
Residue number A
750
Residue number B
802
Peptide name
NEDD4-like E3 ubiquitin-protein ligase WWP2

Ligandability

Cysteine 750 of NEDD4-like E3 ubiquitin-protein ligase WWP2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 802 of NEDD4-like E3 ubiquitin-protein ligase WWP2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NEDD4-like E3 ubiquitin-protein ligase WWP2 between cysteines 588 and 838. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
5tj7
Structure name
structure of wwp2 ww2-2,3-linker-hect aa 334-398 linked to 485-865
Structure deposition date
2016-10-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
82
Peptide accession
O00308
Residue number A
588
Residue number B
838
Peptide name
NEDD4-like E3 ubiquitin-protein ligase WWP2

Ligandability

Cysteine 588 of NEDD4-like E3 ubiquitin-protein ligase WWP2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 838 of NEDD4-like E3 ubiquitin-protein ligase WWP2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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