ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sulfhydryl oxidase 1

Intramolecular
Cysteine 509 and cysteine 512
Cysteine 101 and cysteine 110
Cysteine 449 and cysteine 452
Cysteine 73 and cysteine 76
Cysteine 396 and cysteine 408
Cysteine 73 and cysteine 452
Cysteine 73 and cysteine 455
Cysteine 76 and cysteine 452
Cysteine 76 and cysteine 455
Cysteine 73 and cysteine 101
More...
Cysteine 70 and cysteine 101
Cysteine 73 and cysteine 113
A redox-regulated disulphide may form within Sulfhydryl oxidase 1 between cysteines 509 and 512.

Details

Redox score ?
88
PDB code
3lli
Structure name
sulfhydryl oxidase fragment of human qsox1
Structure deposition date
2010-01-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00391
Residue number A
509
Residue number B
512
Peptide name
Sulfhydryl oxidase 1

Ligandability

Cysteine 509 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 512 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sulfhydryl oxidase 1 between cysteines 101 and 110.

Details

Redox score ?
83
PDB code
4ij3
Structure name
oxidoreductase fragment of human qsox1 in complex with a fab fragment from an anti- human qsox1 antibody
Structure deposition date
2012-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00391
Residue number A
101
Residue number B
110
Peptide name
Sulfhydryl oxidase 1

Ligandability

Cysteine 101 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sulfhydryl oxidase 1 between cysteines 449 and 452.

Details

Redox score ?
83
PDB code
3llk
Structure name
sulfhydryl oxidase fragment of human qsox1
Structure deposition date
2010-01-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00391
Residue number A
449
Residue number B
452
Peptide name
Sulfhydryl oxidase 1

Ligandability

Cysteine 449 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 452 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sulfhydryl oxidase 1 between cysteines 73 and 76.

Details

Redox score ?
81
PDB code
4p2l
Structure name
quiescin sulfhydryl oxidase from rattus norvegicus
Structure deposition date
2014-03-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6IUU3
Residue number A
73
Residue number B
76
Peptide name
Sulfhydryl oxidase 1

Ligandability

Cysteine 73 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 76 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sulfhydryl oxidase 1 between cysteines 396 and 408.

Details

Redox score ?
79
PDB code
4p2l
Structure name
quiescin sulfhydryl oxidase from rattus norvegicus
Structure deposition date
2014-03-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6IUU3
Residue number A
396
Residue number B
408
Peptide name
Sulfhydryl oxidase 1

Ligandability

Cysteine 396 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 408 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sulfhydryl oxidase 1 between cysteines 73 and 452.

Details

Redox score ?
72
PDB code
4p2l
Structure name
quiescin sulfhydryl oxidase from rattus norvegicus
Structure deposition date
2014-03-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6IUU3
Residue number A
73
Residue number B
452
Peptide name
Sulfhydryl oxidase 1

Ligandability

Cysteine 73 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 452 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sulfhydryl oxidase 1 between cysteines 73 and 455.

Details

Redox score ?
63
PDB code
4p2l
Structure name
quiescin sulfhydryl oxidase from rattus norvegicus
Structure deposition date
2014-03-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6IUU3
Residue number A
73
Residue number B
455
Peptide name
Sulfhydryl oxidase 1

Ligandability

Cysteine 73 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 455 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sulfhydryl oxidase 1 between cysteines 76 and 452.

Details

Redox score ?
62
PDB code
4p2l
Structure name
quiescin sulfhydryl oxidase from rattus norvegicus
Structure deposition date
2014-03-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6IUU3
Residue number A
76
Residue number B
452
Peptide name
Sulfhydryl oxidase 1

Ligandability

Cysteine 76 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 452 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sulfhydryl oxidase 1 between cysteines 76 and 455. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
4p2l
Structure name
quiescin sulfhydryl oxidase from rattus norvegicus
Structure deposition date
2014-03-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
50
Peptide accession
Q6IUU3
Residue number A
76
Residue number B
455
Peptide name
Sulfhydryl oxidase 1

Ligandability

Cysteine 76 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 455 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sulfhydryl oxidase 1 between cysteines 73 and 101. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
4ij3
Structure name
oxidoreductase fragment of human qsox1 in complex with a fab fragment from an anti- human qsox1 antibody
Structure deposition date
2012-12-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00391
Residue number A
73
Residue number B
101
Peptide name
Sulfhydryl oxidase 1

Ligandability

Cysteine 73 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sulfhydryl oxidase 1 between cysteines 70 and 101. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
4ij3
Structure name
oxidoreductase fragment of human qsox1 in complex with a fab fragment from an anti- human qsox1 antibody
Structure deposition date
2012-12-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00391
Residue number A
70
Residue number B
101
Peptide name
Sulfhydryl oxidase 1

Ligandability

Cysteine 70 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sulfhydryl oxidase 1 between cysteines 73 and 113. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
3t58
Structure name
c76a/c455s mutant of mouse qsox1 containing an interdomain disulfide
Structure deposition date
2011-07-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8BND5
Residue number A
73
Residue number B
113
Peptide name
Sulfhydryl oxidase 1

Ligandability

Cysteine 73 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Sulfhydryl oxidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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