Dynactin subunit 6
Intermolecular
Cysteine 128 and cysteine 149 of Dynactin subunit 5
Cysteine 129 and cysteine 149 of Dynactin subunit 5
Cysteine 148 and cysteine 149 of Dynactin subunit 5
Cysteine 18 and cysteine 29 of Dynactin subunit 5
Cysteine 128 and cysteine 114 of Dynactin subunit 5
Intramolecular
Cysteine 129 and cysteine 148
Cysteine 128 and cysteine 148
Cysteine 128 and cysteine 129
7z8m U 128 V 149
A redox-regulated disulphide may form between cysteine 128 of Dynactin subunit 6 and cysteine 149 of Dynactin subunit 5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
7z8m
Structure name
the pointed end complex of dynactin bound to bicdr1
Structure deposition date
2022-03-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
78
Minimum pKa ?
10
% buried
66
Peptide A name
Dynactin subunit 6
Peptide B name
Dynactin subunit 5
Peptide A accession
D0G6S1
Peptide B accession
A0A286ZK88
Peptide A residue number
128
Peptide B residue number
149
Ligandability
Cysteine 128 of Dynactin subunit 6
Cysteine 149 of Dynactin subunit 5
6zo4 U 129 V 149
A redox-regulated disulphide may form between cysteine 129 of Dynactin subunit 6 and cysteine 149 of Dynactin subunit 5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
6zo4
Structure name
the pointed end complex of dynactin bound to bicd2
Structure deposition date
2020-07-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
9
% buried
62
Peptide A name
Dynactin subunit 6
Peptide B name
Dynactin subunit 5
Peptide A accession
D0G6S1
Peptide B accession
A0A286ZK88
Peptide A residue number
129
Peptide B residue number
149
Ligandability
Cysteine 129 of Dynactin subunit 6
Cysteine 149 of Dynactin subunit 5
6znm U 148 V 149
A redox-regulated disulphide may form between cysteine 148 of Dynactin subunit 6 and cysteine 149 of Dynactin subunit 5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
6znm
Structure name
the pointed end complex of dynactin bound to bicdr1
Structure deposition date
2020-07-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
55
Peptide A name
Dynactin subunit 6
Peptide B name
Dynactin subunit 5
Peptide A accession
D0G6S1
Peptide B accession
A0A286ZK88
Peptide A residue number
148
Peptide B residue number
149
Ligandability
Cysteine 148 of Dynactin subunit 6
Cysteine 149 of Dynactin subunit 5
7z8m U 18 V 29
A redox-regulated disulphide may form between cysteine 18 of Dynactin subunit 6 and cysteine 29 of Dynactin subunit 5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7z8m
Structure name
the pointed end complex of dynactin bound to bicdr1
Structure deposition date
2022-03-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
12
% buried
82
Peptide A name
Dynactin subunit 6
Peptide B name
Dynactin subunit 5
Peptide A accession
D0G6S1
Peptide B accession
A0A286ZK88
Peptide A residue number
18
Peptide B residue number
29
Ligandability
Cysteine 18 of Dynactin subunit 6
Cysteine 29 of Dynactin subunit 5
7z8m U 128 V 114
A redox-regulated disulphide may form between cysteine 128 of Dynactin subunit 6 and cysteine 114 of Dynactin subunit 5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7z8m
Structure name
the pointed end complex of dynactin bound to bicdr1
Structure deposition date
2022-03-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
10
% buried
75
Peptide A name
Dynactin subunit 6
Peptide B name
Dynactin subunit 5
Peptide A accession
D0G6S1
Peptide B accession
A0A286ZK88
Peptide A residue number
128
Peptide B residue number
114
Ligandability
Cysteine 128 of Dynactin subunit 6
Cysteine 114 of Dynactin subunit 5
3tv0 A 129 A 148
A redox-regulated disulphide may form within Dynactin subunit 6 between cysteines 129 and 148.
Details
Redox score ?
87
PDB code
3tv0
Structure name
structure of dynactin p27 subunit
Structure deposition date
2011-09-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00399
Residue number A
129
Residue number B
148
Peptide name
Dynactin subunit 6
Ligandability
Cysteine 129 of Dynactin subunit 6
Cysteine 148 of Dynactin subunit 6
3tv0 B 128 B 148
A redox-regulated disulphide may form within Dynactin subunit 6 between cysteines 128 and 148. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
3tv0
Structure name
structure of dynactin p27 subunit
Structure deposition date
2011-09-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
nan
Peptide accession
O00399
Residue number A
128
Residue number B
148
Peptide name
Dynactin subunit 6
Ligandability
Cysteine 128 of Dynactin subunit 6
Cysteine 148 of Dynactin subunit 6
3tv0 B 128 B 129
A redox-regulated disulphide may form within Dynactin subunit 6 between cysteines 128 and 129. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
3tv0
Structure name
structure of dynactin p27 subunit
Structure deposition date
2011-09-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
nan
Peptide accession
O00399
Residue number A
128
Residue number B
129
Peptide name
Dynactin subunit 6
Ligandability
Cysteine 128 of Dynactin subunit 6
Cysteine 129 of Dynactin subunit 6
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