ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Actin nucleation-promoting factor WASL

Intramolecular
Cysteine 52 and cysteine 112
Cysteine 35 and cysteine 63
A redox-regulated disulphide may form within Actin nucleation-promoting factor WASL between cysteines 52 and 112 (57 and 117 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
1mke
Structure name
structure of the n-wasp evh1 domain-wip complex
Structure deposition date
2002-08-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
40
Minimum pKa ?
9
% buried
4
Peptide accession
O08816
Residue number A
52
Residue number B
112
Peptide name
Actin nucleation-promoting factor WASL

Ligandability

Cysteine 52 of Actin nucleation-promoting factor WASL

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 112 of Actin nucleation-promoting factor WASL

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Actin nucleation-promoting factor WASL between cysteines 35 and 63 (40 and 68 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
1mke
Structure name
structure of the n-wasp evh1 domain-wip complex
Structure deposition date
2002-08-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
20
Peptide accession
O08816
Residue number A
35
Residue number B
63
Peptide name
Actin nucleation-promoting factor WASL

Ligandability

Cysteine 35 of Actin nucleation-promoting factor WASL

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 63 of Actin nucleation-promoting factor WASL

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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