ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Forkhead box protein N3

Intramolecular
Cysteine 121 and cysteine 171
A redox-regulated disulphide may form within Forkhead box protein N3 between cysteines 121 and 171. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6nce
Structure name
crystal structure of the human foxn3 dna binding domain in complex with a forkhead dna sequence
Structure deposition date
2018-12-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
50
Peptide accession
O00409
Residue number A
121
Residue number B
171
Peptide name
Forkhead box protein N3

Ligandability

Cysteine 121 of Forkhead box protein N3

Cysteine 171 of Forkhead box protein N3

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