DNA-directed RNA polymerase, mitochondrial
Intermolecular
Cysteine 591 and cysteine 383 of Dimethyladenosine transferase 2, mitochondrial L
Intramolecular
Cysteine 232 and cysteine 233
Cysteine 897 and cysteine 898
Cysteine 232 and cysteine 472
Cysteine 233 and cysteine 472
Cysteine 1139 and cysteine 1167
6erq B 591 J 383
A redox-regulated disulphide may form between cysteine 591 of DNA-directed RNA polymerase, mitochondrial and cysteine 383 of Dimethyladenosine transferase 2, mitochondrial. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6erq
Structure name
structure of the human mitochondrial transcription initiation complex at the hsp promoter
Structure deposition date
2017-10-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
46
Minimum pKa ?
8
% buried
20
Peptide A name
DNA-directed RNA polymerase, mitochondrial
Peptide B name
Dimethyladenosine transferase 2, mitochondrial
Peptide A accession
O00411
Peptide B accession
Q9H5Q4
Peptide A residue number
591
Peptide B residue number
383
Ligandability
Cysteine 591 of DNA-directed RNA polymerase, mitochondrial
Cysteine 383 of Dimethyladenosine transferase 2, mitochondrial
6erp B 232 B 233
A redox-regulated disulphide may form within DNA-directed RNA polymerase, mitochondrial between cysteines 232 and 233. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
6erp
Structure name
structure of the human mitochondrial transcription initiation complex at the lsp promoter
Structure deposition date
2017-10-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
73
Minimum pKa ?
13
% buried
94
Peptide accession
O00411
Residue number A
232
Residue number B
233
Peptide name
DNA-directed RNA polymerase, mitochondrial
Ligandability
Cysteine 232 of DNA-directed RNA polymerase, mitochondrial
Cysteine 233 of DNA-directed RNA polymerase, mitochondrial
5ola F 897 F 898
A redox-regulated disulphide may form within DNA-directed RNA polymerase, mitochondrial between cysteines 897 and 898. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
5ola
Structure name
structure of mitochondrial transcription elongation complex in complex with elongation factor tefm
Structure deposition date
2017-07-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
90
Minimum pKa ?
13
% buried
100
Peptide accession
O00411
Residue number A
897
Residue number B
898
Peptide name
DNA-directed RNA polymerase, mitochondrial
Ligandability
Cysteine 897 of DNA-directed RNA polymerase, mitochondrial
Cysteine 898 of DNA-directed RNA polymerase, mitochondrial
6erq A 232 A 472
A redox-regulated disulphide may form within DNA-directed RNA polymerase, mitochondrial between cysteines 232 and 472. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6erq
Structure name
structure of the human mitochondrial transcription initiation complex at the hsp promoter
Structure deposition date
2017-10-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
80
Peptide accession
O00411
Residue number A
232
Residue number B
472
Peptide name
DNA-directed RNA polymerase, mitochondrial
Ligandability
Cysteine 232 of DNA-directed RNA polymerase, mitochondrial
Cysteine 472 of DNA-directed RNA polymerase, mitochondrial
6erq A 233 A 472
A redox-regulated disulphide may form within DNA-directed RNA polymerase, mitochondrial between cysteines 233 and 472. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
6erq
Structure name
structure of the human mitochondrial transcription initiation complex at the hsp promoter
Structure deposition date
2017-10-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
76
Peptide accession
O00411
Residue number A
233
Residue number B
472
Peptide name
DNA-directed RNA polymerase, mitochondrial
Ligandability
Cysteine 233 of DNA-directed RNA polymerase, mitochondrial
Cysteine 472 of DNA-directed RNA polymerase, mitochondrial
6erp A 1139 A 1167
A redox-regulated disulphide may form within DNA-directed RNA polymerase, mitochondrial between cysteines 1139 and 1167. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
6erp
Structure name
structure of the human mitochondrial transcription initiation complex at the lsp promoter
Structure deposition date
2017-10-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
100
Peptide accession
O00411
Residue number A
1139
Residue number B
1167
Peptide name
DNA-directed RNA polymerase, mitochondrial
Ligandability
Cysteine 1139 of DNA-directed RNA polymerase, mitochondrial
Cysteine 1167 of DNA-directed RNA polymerase, mitochondrial
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