ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Eukaryotic elongation factor 2 kinase

Intramolecular
Cysteine 314 and cysteine 318
Cysteine 631 and cysteine 650
A redox-regulated disulphide may form within Eukaryotic elongation factor 2 kinase between cysteines 314 and 318.

Details

Redox score ?
63
PDB code
7shq
Structure name
structure of a functional construct of eukaryotic elongation factor 2 kinase in complex with calmodulin
Structure deposition date
2021-10-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
14
% buried
nan
Peptide accession
O00418
Residue number A
314
Residue number B
318
Peptide name
Eukaryotic elongation factor 2 kinase

Ligandability

Cysteine 314 of Eukaryotic elongation factor 2 kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 318 of Eukaryotic elongation factor 2 kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Eukaryotic elongation factor 2 kinase between cysteines 631 and 650. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
5ks5
Structure name
structure of the c-terminal helical repeat domain of elongation factor 2 kinase
Structure deposition date
2016-07-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
38
Minimum pKa ?
10
% buried
6
Peptide accession
O00418
Residue number A
631
Residue number B
650
Peptide name
Eukaryotic elongation factor 2 kinase

Ligandability

Cysteine 631 of Eukaryotic elongation factor 2 kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 650 of Eukaryotic elongation factor 2 kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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