ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dynamin-1-like protein

Intramolecular
Cysteine 361 and cysteine 446
Cysteine 361 and cysteine 367 L
A redox-regulated disulphide may form within Dynamin-1-like protein between cysteines 361 and 446. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
4bej
Structure name
nucleotide-free dynamin 1-like protein (dnm1l, drp1, dlp1)
Structure deposition date
2013-03-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
27
Peptide accession
O00429
Residue number A
361
Residue number B
446
Peptide name
Dynamin-1-like protein

Ligandability

Cysteine 361 of Dynamin-1-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 446 of Dynamin-1-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dynamin-1-like protein between cysteines 361 and 367. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
4bej
Structure name
nucleotide-free dynamin 1-like protein (dnm1l, drp1, dlp1)
Structure deposition date
2013-03-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
27
Peptide accession
O00429
Residue number A
361
Residue number B
367
Peptide name
Dynamin-1-like protein

Ligandability

Cysteine 361 of Dynamin-1-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 367 of Dynamin-1-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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