ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Serine/threonine-protein kinase PLK4

Intramolecular
Cysteine 712 and cysteine 779
A redox-regulated disulphide may form within Serine/threonine-protein kinase PLK4 between cysteines 712 and 779 (127 and 194 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
6n46
Structure name
crystal structure of the cryptic polo box domain of a human activated plk4
Structure deposition date
2018-11-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
85
Minimum pKa ?
13
% buried
100
Peptide accession
O00444
Residue number A
712
Residue number B
779
Peptide name
Serine/threonine-protein kinase PLK4

Ligandability

Cysteine 712 of Serine/threonine-protein kinase PLK4

Cysteine 779 of Serine/threonine-protein kinase PLK4

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