ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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GDNF family receptor alpha-2

Intramolecular
Cysteine 258 and cysteine 264
Cysteine 325 and cysteine 335
Cysteine 47 and cysteine 53
Cysteine 285 and cysteine 347
Cysteine 224 and cysteine 229
Cysteine 195 and cysteine 241
Cysteine 185 and cysteine 200
Cysteine 95 and cysteine 105
Cysteine 275 and cysteine 293
Cysteine 168 and cysteine 174
More...
Cysteine 40 and cysteine 93
Cysteine 161 and cysteine 222
Cysteine 251 and cysteine 323
Cysteine 63 and cysteine 78
Cysteine 161 and cysteine 224
Cysteine 200 and cysteine 241
Cysteine 161 and cysteine 229
Cysteine 293 and cysteine 347
Cysteine 251 and cysteine 325
Cysteine 251 and cysteine 335
Cysteine 40 and cysteine 95
Cysteine 40 and cysteine 105
Cysteine 185 and cysteine 241
Cysteine 195 and cysteine 200
Cysteine 285 and cysteine 293
Cysteine 222 and cysteine 224
Cysteine 275 and cysteine 347
Cysteine 222 and cysteine 229
Cysteine 323 and cysteine 335
Cysteine 93 and cysteine 105
Cysteine 93 and cysteine 95
Cysteine 185 and cysteine 195
Cysteine 323 and cysteine 325
Cysteine 275 and cysteine 285
Cysteine 47 and cysteine 93
A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 258 and 264.

Details

Redox score ?
87
PDB code
5mr5
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
258
Residue number B
264
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 258 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 264 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 325 and 335.

Details

Redox score ?
86
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
3
Half-sphere exposure sum ?
55
Minimum pKa ?
8
% buried
22
Peptide accession
O00451
Residue number A
325
Residue number B
335
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 325 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 335 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 47 and 53.

Details

Redox score ?
85
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
3
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
25
Peptide accession
O00451
Residue number A
47
Residue number B
53
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 47 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 53 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 285 and 347.

Details

Redox score ?
85
PDB code
5mr5
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
285
Residue number B
347
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 285 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 347 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 224 and 229.

Details

Redox score ?
84
PDB code
5mr5
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
224
Residue number B
229
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 224 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 229 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 195 and 241.

Details

Redox score ?
84
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
195
Residue number B
241
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 195 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 241 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 185 and 200.

Details

Redox score ?
84
PDB code
5mr5
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
185
Residue number B
200
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 185 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 95 and 105.

Details

Redox score ?
84
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
95
Residue number B
105
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 95 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 275 and 293.

Details

Redox score ?
83
PDB code
5mr5
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
275
Residue number B
293
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 275 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 293 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 168 and 174.

Details

Redox score ?
83
PDB code
5mr5
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
168
Residue number B
174
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 168 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 40 and 93.

Details

Redox score ?
83
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
40
Residue number B
93
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 40 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 161 and 222.

Details

Redox score ?
82
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
161
Residue number B
222
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 161 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 222 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 251 and 323.

Details

Redox score ?
82
PDB code
5mr5
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
251
Residue number B
323
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 251 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 323 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 63 and 78.

Details

Redox score ?
81
PDB code
6q2o
Structure name
cryo-em structure of ret/gfra2/nrtn extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
0
Peptide accession
O00451
Residue number A
63
Residue number B
78
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 63 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 78 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 161 and 224.

Details

Redox score ?
77
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
3
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
161
Residue number B
224
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 161 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 224 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 200 and 241.

Details

Redox score ?
77
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
3
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
200
Residue number B
241
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 200 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 241 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 161 and 229.

Details

Redox score ?
76
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
3
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
161
Residue number B
229
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 161 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 229 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 293 and 347.

Details

Redox score ?
72
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
293
Residue number B
347
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 293 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 347 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 251 and 325.

Details

Redox score ?
70
PDB code
5mr5
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
251
Residue number B
325
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 251 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 325 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 251 and 335.

Details

Redox score ?
70
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
251
Residue number B
335
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 251 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 335 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 40 and 95.

Details

Redox score ?
69
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
40
Residue number B
95
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 40 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 95 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 40 and 105.

Details

Redox score ?
69
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
40
Residue number B
105
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 40 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 185 and 241.

Details

Redox score ?
69
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
185
Residue number B
241
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 185 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 241 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 195 and 200.

Details

Redox score ?
68
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
195
Residue number B
200
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 195 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 285 and 293.

Details

Redox score ?
67
PDB code
5mr5
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
285
Residue number B
293
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 285 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 293 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 222 and 224.

Details

Redox score ?
67
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
222
Residue number B
224
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 222 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 224 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 275 and 347.

Details

Redox score ?
65
PDB code
5mr5
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
275
Residue number B
347
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 275 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 347 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 222 and 229.

Details

Redox score ?
63
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
222
Residue number B
229
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 222 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 229 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 323 and 335.

Details

Redox score ?
62
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
8
% buried
nan
Peptide accession
O00451
Residue number A
323
Residue number B
335
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 323 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 335 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 93 and 105.

Details

Redox score ?
60
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
93
Residue number B
105
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 93 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 93 and 95. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
93
Residue number B
95
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 93 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 95 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 185 and 195. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
185
Residue number B
195
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 185 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 323 and 325. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
5mr5
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
323
Residue number B
325
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 323 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 325 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 275 and 285. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
5mr5
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
275
Residue number B
285
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 275 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 285 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-2 between cysteines 47 and 93. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
5mr4
Structure name
ligand-receptor complex
Structure deposition date
2016-12-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00451
Residue number A
47
Residue number B
93
Peptide name
GDNF family receptor alpha-2

Ligandability

Cysteine 47 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of GDNF family receptor alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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