ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Phosphatidylinositol 3-kinase regulatory subunit beta

Intermolecular
Cysteine 396 and cysteine 396
A redox-regulated disulphide may form between two units of Phosphatidylinositol 3-kinase regulatory subunit beta at cysteines 396 and 396 (399 and 399 respectively in this structure).

Details

Redox score ?
72
PDB code
7rnu
Structure name
nsh2 domain of p85-beta subunit of phosphatidylinositol 3-kinase in complex with an actin peptide with phosphorylated tyrosine 53
Structure deposition date
2021-07-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
7
% buried
44
Peptide A name
Phosphatidylinositol 3-kinase regulatory subunit beta
Peptide B name
Phosphatidylinositol 3-kinase regulatory subunit beta
Peptide A accession
O00459
Peptide B accession
O00459
Peptide A residue number
396
Peptide B residue number
396

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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