ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Beta-mannosidase

Intramolecular
Cysteine 732 and cysteine 761
Cysteine 764 and cysteine 769
Cysteine 540 and cysteine 629
Cysteine 167 and cysteine 176
Cysteine 761 and cysteine 764
Cysteine 732 and cysteine 764
Cysteine 761 and cysteine 769
Cysteine 732 and cysteine 769
A redox-regulated disulphide may form within Beta-mannosidase between cysteines 732 and 761.

Details

Redox score ?
85
PDB code
6ddt
Structure name
mouse beta-mannosidase (manba)
Structure deposition date
2018-05-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K2I4
Residue number A
732
Residue number B
761
Peptide name
Beta-mannosidase

Ligandability

Cysteine 732 of Beta-mannosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 761 of Beta-mannosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-mannosidase between cysteines 764 and 769.

Details

Redox score ?
84
PDB code
6ddu
Structure name
mouse beta-mannosidase bound to beta-d-mannose (manba)
Structure deposition date
2018-05-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K2I4
Residue number A
764
Residue number B
769
Peptide name
Beta-mannosidase

Ligandability

Cysteine 764 of Beta-mannosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 769 of Beta-mannosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-mannosidase between cysteines 540 and 629.

Details

Redox score ?
82
PDB code
6ddt
Structure name
mouse beta-mannosidase (manba)
Structure deposition date
2018-05-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K2I4
Residue number A
540
Residue number B
629
Peptide name
Beta-mannosidase

Ligandability

Cysteine 540 of Beta-mannosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 629 of Beta-mannosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-mannosidase between cysteines 167 and 176.

Details

Redox score ?
80
PDB code
6ddu
Structure name
mouse beta-mannosidase bound to beta-d-mannose (manba)
Structure deposition date
2018-05-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K2I4
Residue number A
167
Residue number B
176
Peptide name
Beta-mannosidase

Ligandability

Cysteine 167 of Beta-mannosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 176 of Beta-mannosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-mannosidase between cysteines 761 and 764.

Details

Redox score ?
68
PDB code
6ddt
Structure name
mouse beta-mannosidase (manba)
Structure deposition date
2018-05-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K2I4
Residue number A
761
Residue number B
764
Peptide name
Beta-mannosidase

Ligandability

Cysteine 761 of Beta-mannosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 764 of Beta-mannosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-mannosidase between cysteines 732 and 764.

Details

Redox score ?
62
PDB code
6ddt
Structure name
mouse beta-mannosidase (manba)
Structure deposition date
2018-05-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K2I4
Residue number A
732
Residue number B
764
Peptide name
Beta-mannosidase

Ligandability

Cysteine 732 of Beta-mannosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 764 of Beta-mannosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-mannosidase between cysteines 761 and 769. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
6ddu
Structure name
mouse beta-mannosidase bound to beta-d-mannose (manba)
Structure deposition date
2018-05-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K2I4
Residue number A
761
Residue number B
769
Peptide name
Beta-mannosidase

Ligandability

Cysteine 761 of Beta-mannosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 769 of Beta-mannosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-mannosidase between cysteines 732 and 769. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6ddu
Structure name
mouse beta-mannosidase bound to beta-d-mannose (manba)
Structure deposition date
2018-05-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8K2I4
Residue number A
732
Residue number B
769
Peptide name
Beta-mannosidase

Ligandability

Cysteine 732 of Beta-mannosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 769 of Beta-mannosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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