TNF receptor-associated factor 5
Intermolecular
Cysteine 401 and cysteine 438
Cysteine 98 and cysteine 85 of TNF receptor-associated factor 6
Intramolecular
Cysteine 139 and cysteine 144
Cysteine 45 and cysteine 48
Cysteine 116 and cysteine 132
Cysteine 144 and cysteine 161
Cysteine 45 and cysteine 68
Cysteine 110 and cysteine 132
Cysteine 45 and cysteine 65
Cysteine 110 and cysteine 116
More...Cysteine 48 and cysteine 68
Cysteine 48 and cysteine 65
Cysteine 60 and cysteine 81
Cysteine 139 and cysteine 161
Cysteine 65 and cysteine 68
Cysteine 45 and cysteine 81
Cysteine 98 and cysteine 99
Cysteine 65 and cysteine 99
4gjh A 349 C 386
A redox-regulated disulphide may form between two units of TNF receptor-associated factor 5 at cysteines 401 and 438 (349 and 386 respectively in this structure).
Details
Redox score ?
68
PDB code
4gjh
Structure name
crystal structure of the traf domain of traf5
Structure deposition date
2012-08-09
Thiol separation (Å)
5
Half-sphere exposure sum ?
69
Minimum pKa ?
7
% buried
80
Peptide A name
TNF receptor-associated factor 5
Peptide B name
TNF receptor-associated factor 5
Peptide A accession
P70191
Peptide B accession
P70191
Peptide A residue number
401
Peptide B residue number
438
Ligandability
Cysteine 401 of TNF receptor-associated factor 5
Cysteine 438 of TNF receptor-associated factor 5
7l3l C 98 D 85
A redox-regulated disulphide may form between cysteine 98 of TNF receptor-associated factor 5 and cysteine 85 of TNF receptor-associated factor 6. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
5
% buried
67
Peptide A name
TNF receptor-associated factor 5
Peptide B name
TNF receptor-associated factor 6
Peptide A accession
O00463
Peptide B accession
Q9Y4K3
Peptide A residue number
98
Peptide B residue number
85
Ligandability
Cysteine 98 of TNF receptor-associated factor 5
Cysteine 85 of TNF receptor-associated factor 6
7l3l A 139 A 144
A redox-regulated disulphide may form within TNF receptor-associated factor 5 between cysteines 139 and 144.
Details
Redox score ?
90
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
3
Half-sphere exposure sum ?
43
Minimum pKa ?
8
% buried
0
Peptide accession
O00463
Residue number A
139
Residue number B
144
Peptide name
TNF receptor-associated factor 5
Ligandability
Cysteine 139 of TNF receptor-associated factor 5
Cysteine 144 of TNF receptor-associated factor 5
7l3l A 45 A 48
A redox-regulated disulphide may form within TNF receptor-associated factor 5 between cysteines 45 and 48.
Details
Redox score ?
89
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
3
% buried
46
Peptide accession
O00463
Residue number A
45
Residue number B
48
Peptide name
TNF receptor-associated factor 5
Ligandability
Cysteine 45 of TNF receptor-associated factor 5
Cysteine 48 of TNF receptor-associated factor 5
7l3l A 116 A 132
A redox-regulated disulphide may form within TNF receptor-associated factor 5 between cysteines 116 and 132.
Details
Redox score ?
86
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
3
Half-sphere exposure sum ?
64
Minimum pKa ?
7
% buried
36
Peptide accession
O00463
Residue number A
116
Residue number B
132
Peptide name
TNF receptor-associated factor 5
Ligandability
Cysteine 116 of TNF receptor-associated factor 5
Cysteine 132 of TNF receptor-associated factor 5
7l3l A 144 A 161
A redox-regulated disulphide may form within TNF receptor-associated factor 5 between cysteines 144 and 161.
Details
Redox score ?
85
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
0
Peptide accession
O00463
Residue number A
144
Residue number B
161
Peptide name
TNF receptor-associated factor 5
Ligandability
Cysteine 144 of TNF receptor-associated factor 5
Cysteine 161 of TNF receptor-associated factor 5
7l3l A 45 A 68
A redox-regulated disulphide may form within TNF receptor-associated factor 5 between cysteines 45 and 68.
Details
Redox score ?
85
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
3
% buried
46
Peptide accession
O00463
Residue number A
45
Residue number B
68
Peptide name
TNF receptor-associated factor 5
Ligandability
Cysteine 45 of TNF receptor-associated factor 5
Cysteine 68 of TNF receptor-associated factor 5
7l3l C 110 C 132
A redox-regulated disulphide may form within TNF receptor-associated factor 5 between cysteines 110 and 132.
Details
Redox score ?
84
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
7
% buried
15
Peptide accession
O00463
Residue number A
110
Residue number B
132
Peptide name
TNF receptor-associated factor 5
Ligandability
Cysteine 110 of TNF receptor-associated factor 5
Cysteine 132 of TNF receptor-associated factor 5
7l3l C 45 C 65
A redox-regulated disulphide may form within TNF receptor-associated factor 5 between cysteines 45 and 65.
Details
Redox score ?
82
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
4
% buried
65
Peptide accession
O00463
Residue number A
45
Residue number B
65
Peptide name
TNF receptor-associated factor 5
Ligandability
Cysteine 45 of TNF receptor-associated factor 5
Cysteine 65 of TNF receptor-associated factor 5
7l3l A 110 A 116
A redox-regulated disulphide may form within TNF receptor-associated factor 5 between cysteines 110 and 116.
Details
Redox score ?
79
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
9
% buried
40
Peptide accession
O00463
Residue number A
110
Residue number B
116
Peptide name
TNF receptor-associated factor 5
Ligandability
Cysteine 110 of TNF receptor-associated factor 5
Cysteine 116 of TNF receptor-associated factor 5
7l3l C 48 C 68
A redox-regulated disulphide may form within TNF receptor-associated factor 5 between cysteines 48 and 68.
Details
Redox score ?
78
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
7
% buried
32
Peptide accession
O00463
Residue number A
48
Residue number B
68
Peptide name
TNF receptor-associated factor 5
Ligandability
Cysteine 48 of TNF receptor-associated factor 5
Cysteine 68 of TNF receptor-associated factor 5
7l3l A 48 A 65
A redox-regulated disulphide may form within TNF receptor-associated factor 5 between cysteines 48 and 65.
Details
Redox score ?
77
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
8
% buried
49
Peptide accession
O00463
Residue number A
48
Residue number B
65
Peptide name
TNF receptor-associated factor 5
Ligandability
Cysteine 48 of TNF receptor-associated factor 5
Cysteine 65 of TNF receptor-associated factor 5
7l3l C 60 C 81
A redox-regulated disulphide may form within TNF receptor-associated factor 5 between cysteines 60 and 81.
Details
Redox score ?
73
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
41
Peptide accession
O00463
Residue number A
60
Residue number B
81
Peptide name
TNF receptor-associated factor 5
Ligandability
Cysteine 60 of TNF receptor-associated factor 5
Cysteine 81 of TNF receptor-associated factor 5
7l3l A 139 A 161
A redox-regulated disulphide may form within TNF receptor-associated factor 5 between cysteines 139 and 161.
Details
Redox score ?
73
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
48
Minimum pKa ?
8
% buried
0
Peptide accession
O00463
Residue number A
139
Residue number B
161
Peptide name
TNF receptor-associated factor 5
Ligandability
Cysteine 139 of TNF receptor-associated factor 5
Cysteine 161 of TNF receptor-associated factor 5
7l3l C 65 C 68
A redox-regulated disulphide may form within TNF receptor-associated factor 5 between cysteines 65 and 68.
Details
Redox score ?
68
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
52
Peptide accession
O00463
Residue number A
65
Residue number B
68
Peptide name
TNF receptor-associated factor 5
Ligandability
Cysteine 65 of TNF receptor-associated factor 5
Cysteine 68 of TNF receptor-associated factor 5
7l3l A 45 A 81
A redox-regulated disulphide may form within TNF receptor-associated factor 5 between cysteines 45 and 81. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
3
% buried
51
Peptide accession
O00463
Residue number A
45
Residue number B
81
Peptide name
TNF receptor-associated factor 5
Ligandability
Cysteine 45 of TNF receptor-associated factor 5
Cysteine 81 of TNF receptor-associated factor 5
7l3l A 98 A 99
A redox-regulated disulphide may form within TNF receptor-associated factor 5 between cysteines 98 and 99. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
95
Peptide accession
O00463
Residue number A
98
Residue number B
99
Peptide name
TNF receptor-associated factor 5
Ligandability
Cysteine 98 of TNF receptor-associated factor 5
Cysteine 99 of TNF receptor-associated factor 5
7l3l C 65 C 99
A redox-regulated disulphide may form within TNF receptor-associated factor 5 between cysteines 65 and 99. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
25
PDB code
7l3l
Structure name
structure of traf5 and traf6 ring hetero dimer
Structure deposition date
2020-12-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
13
% buried
83
Peptide accession
O00463
Residue number A
65
Residue number B
99
Peptide name
TNF receptor-associated factor 5
Ligandability
Cysteine 65 of TNF receptor-associated factor 5
Cysteine 99 of TNF receptor-associated factor 5
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