a tool for identifying drug-targetable redox-active disulphides

Agrin

Intramolecular

Cysteine 1930 and cysteine 1956

A redox-regulated disulphide may form within Agrin between cysteines 1930 and 1956 (1919 and 1945 respectively in this structure).

Details

Redox score ?

84

PDB code

Structure name

crystal structure of agrin and lrp4 complex

Structure deposition date

2011-12-18

Thiol separation (Å)

2

Half-sphere exposure sum ?

59

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

1930

Residue number B

1956

Peptide name

Agrin

Ligandability

Cysteine 1930 of Agrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1956 of Agrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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