RNA polymerase II elongation factor ELL2

Intermolecular

Cysteine 19 and cysteine 46 of ELL-associated factor 1

Intramolecular

A redox-regulated disulphide may form between cysteine 19 of RNA polymerase II elongation factor ELL2 and cysteine 46 of ELL-associated factor 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7okx

Structure name

structure of active transcription elongation complex pol ii-dsif (spt5-kow5)-ell2-eaf1 (composite structure)

Structure deposition date

2021-05-18

Thiol separation (Å)

Half-sphere exposure sum ?

nan

Minimum pK_a ?

% buried

Peptide A name

RNA polymerase II elongation factor ELL2

Peptide B name

ELL-associated factor 1

Peptide A accession

O00472

Peptide B accession

Q96JC9

Peptide A residue number

Peptide B residue number

Ligandability

Cysteine 19 of RNA polymerase II elongation factor ELL2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 46 of ELL-associated factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RNA polymerase II elongation factor ELL2 between cysteines 19 and 114.

Details

Redox score ?

PDB code

7okx

Structure name

structure of active transcription elongation complex pol ii-dsif (spt5-kow5)-ell2-eaf1 (composite structure)

Structure deposition date

2021-05-18

Thiol separation (Å)

Half-sphere exposure sum ?

nan

Minimum pK_a ?

% buried

Peptide accession

O00472

Residue number A

Residue number B

114

Peptide name

RNA polymerase II elongation factor ELL2

Ligandability

Cysteine 19 of RNA polymerase II elongation factor ELL2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of RNA polymerase II elongation factor ELL2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RNA polymerase II elongation factor ELL2 between cysteines 99 and 114. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?