Nuclear receptor subfamily 5 group A member 2
Intramolecular
Cysteine 122 and cysteine 138
Cysteine 86 and cysteine 103
Cysteine 89 and cysteine 103
Cysteine 122 and cysteine 128
Cysteine 103 and cysteine 106
Cysteine 122 and cysteine 141
Cysteine 128 and cysteine 141
Cysteine 138 and cysteine 141
Cysteine 128 and cysteine 138
Cysteine 86 and cysteine 89
More...Cysteine 89 and cysteine 106
Cysteine 106 and cysteine 146
Cysteine 86 and cysteine 146
Cysteine 103 and cysteine 146
Cysteine 86 and cysteine 106
Cysteine 89 and cysteine 146
5l0m A 122 A 138
A redox-regulated disulphide may form within Nuclear receptor subfamily 5 group A member 2 between cysteines 122 and 138.
Details
Redox score ?
88
PDB code
5l0m
Structure name
hlrh-1 dna binding domain - 12bp oct4 promoter complex
Structure deposition date
2016-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
6
% buried
6
Peptide accession
O00482
Residue number A
122
Residue number B
138
Peptide name
Nuclear receptor subfamily 5 group A member 2
Ligandability
Cysteine 122 of Nuclear receptor subfamily 5 group A member 2
Cysteine 138 of Nuclear receptor subfamily 5 group A member 2
5l0m A 86 A 103
A redox-regulated disulphide may form within Nuclear receptor subfamily 5 group A member 2 between cysteines 86 and 103.
Details
Redox score ?
87
PDB code
5l0m
Structure name
hlrh-1 dna binding domain - 12bp oct4 promoter complex
Structure deposition date
2016-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
4
% buried
nan
Peptide accession
O00482
Residue number A
86
Residue number B
103
Peptide name
Nuclear receptor subfamily 5 group A member 2
Ligandability
Cysteine 86 of Nuclear receptor subfamily 5 group A member 2
Cysteine 103 of Nuclear receptor subfamily 5 group A member 2
5l0m A 89 A 103
A redox-regulated disulphide may form within Nuclear receptor subfamily 5 group A member 2 between cysteines 89 and 103.
Details
Redox score ?
83
PDB code
5l0m
Structure name
hlrh-1 dna binding domain - 12bp oct4 promoter complex
Structure deposition date
2016-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
4
% buried
69
Peptide accession
O00482
Residue number A
89
Residue number B
103
Peptide name
Nuclear receptor subfamily 5 group A member 2
Ligandability
Cysteine 89 of Nuclear receptor subfamily 5 group A member 2
Cysteine 103 of Nuclear receptor subfamily 5 group A member 2
2a66 A 122 A 128
A redox-regulated disulphide may form within Nuclear receptor subfamily 5 group A member 2 between cysteines 122 and 128.
Details
Redox score ?
83
PDB code
2a66
Structure name
human liver receptor homologue dna-binding domain (hlrh-1 dbd) in complex with dsdna from the hcyp7a1 promoter
Structure deposition date
2005-07-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
9
% buried
0
Peptide accession
O00482
Residue number A
122
Residue number B
128
Peptide name
Nuclear receptor subfamily 5 group A member 2
Ligandability
Cysteine 122 of Nuclear receptor subfamily 5 group A member 2
Cysteine 128 of Nuclear receptor subfamily 5 group A member 2
5l0m A 103 A 106
A redox-regulated disulphide may form within Nuclear receptor subfamily 5 group A member 2 between cysteines 103 and 106.
Details
Redox score ?
82
PDB code
5l0m
Structure name
hlrh-1 dna binding domain - 12bp oct4 promoter complex
Structure deposition date
2016-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
4
% buried
85
Peptide accession
O00482
Residue number A
103
Residue number B
106
Peptide name
Nuclear receptor subfamily 5 group A member 2
Ligandability
Cysteine 103 of Nuclear receptor subfamily 5 group A member 2
Cysteine 106 of Nuclear receptor subfamily 5 group A member 2
2a66 A 122 A 141
A redox-regulated disulphide may form within Nuclear receptor subfamily 5 group A member 2 between cysteines 122 and 141.
Details
Redox score ?
79
PDB code
2a66
Structure name
human liver receptor homologue dna-binding domain (hlrh-1 dbd) in complex with dsdna from the hcyp7a1 promoter
Structure deposition date
2005-07-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
8
% buried
2
Peptide accession
O00482
Residue number A
122
Residue number B
141
Peptide name
Nuclear receptor subfamily 5 group A member 2
Ligandability
Cysteine 122 of Nuclear receptor subfamily 5 group A member 2
Cysteine 141 of Nuclear receptor subfamily 5 group A member 2
2a66 A 128 A 141
A redox-regulated disulphide may form within Nuclear receptor subfamily 5 group A member 2 between cysteines 128 and 141.
Details
Redox score ?
79
PDB code
2a66
Structure name
human liver receptor homologue dna-binding domain (hlrh-1 dbd) in complex with dsdna from the hcyp7a1 promoter
Structure deposition date
2005-07-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
8
% buried
2
Peptide accession
O00482
Residue number A
128
Residue number B
141
Peptide name
Nuclear receptor subfamily 5 group A member 2
Ligandability
Cysteine 128 of Nuclear receptor subfamily 5 group A member 2
Cysteine 141 of Nuclear receptor subfamily 5 group A member 2
2a66 A 138 A 141
A redox-regulated disulphide may form within Nuclear receptor subfamily 5 group A member 2 between cysteines 138 and 141.
Details
Redox score ?
76
PDB code
2a66
Structure name
human liver receptor homologue dna-binding domain (hlrh-1 dbd) in complex with dsdna from the hcyp7a1 promoter
Structure deposition date
2005-07-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
8
% buried
9
Peptide accession
O00482
Residue number A
138
Residue number B
141
Peptide name
Nuclear receptor subfamily 5 group A member 2
Ligandability
Cysteine 138 of Nuclear receptor subfamily 5 group A member 2
Cysteine 141 of Nuclear receptor subfamily 5 group A member 2
2a66 A 128 A 138
A redox-regulated disulphide may form within Nuclear receptor subfamily 5 group A member 2 between cysteines 128 and 138.
Details
Redox score ?
73
PDB code
2a66
Structure name
human liver receptor homologue dna-binding domain (hlrh-1 dbd) in complex with dsdna from the hcyp7a1 promoter
Structure deposition date
2005-07-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
11
% buried
7
Peptide accession
O00482
Residue number A
128
Residue number B
138
Peptide name
Nuclear receptor subfamily 5 group A member 2
Ligandability
Cysteine 128 of Nuclear receptor subfamily 5 group A member 2
Cysteine 138 of Nuclear receptor subfamily 5 group A member 2
5l0m A 86 A 89
A redox-regulated disulphide may form within Nuclear receptor subfamily 5 group A member 2 between cysteines 86 and 89.
Details
Redox score ?
67
PDB code
5l0m
Structure name
hlrh-1 dna binding domain - 12bp oct4 promoter complex
Structure deposition date
2016-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
13
% buried
nan
Peptide accession
O00482
Residue number A
86
Residue number B
89
Peptide name
Nuclear receptor subfamily 5 group A member 2
Ligandability
Cysteine 86 of Nuclear receptor subfamily 5 group A member 2
Cysteine 89 of Nuclear receptor subfamily 5 group A member 2
5l0m A 89 A 106
A redox-regulated disulphide may form within Nuclear receptor subfamily 5 group A member 2 between cysteines 89 and 106.
Details
Redox score ?
63
PDB code
5l0m
Structure name
hlrh-1 dna binding domain - 12bp oct4 promoter complex
Structure deposition date
2016-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
13
% buried
74
Peptide accession
O00482
Residue number A
89
Residue number B
106
Peptide name
Nuclear receptor subfamily 5 group A member 2
Ligandability
Cysteine 89 of Nuclear receptor subfamily 5 group A member 2
Cysteine 106 of Nuclear receptor subfamily 5 group A member 2
5l0m A 106 A 146
A redox-regulated disulphide may form within Nuclear receptor subfamily 5 group A member 2 between cysteines 106 and 146.
Details
Redox score ?
60
PDB code
5l0m
Structure name
hlrh-1 dna binding domain - 12bp oct4 promoter complex
Structure deposition date
2016-07-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
95
Peptide accession
O00482
Residue number A
106
Residue number B
146
Peptide name
Nuclear receptor subfamily 5 group A member 2
Ligandability
Cysteine 106 of Nuclear receptor subfamily 5 group A member 2
Cysteine 146 of Nuclear receptor subfamily 5 group A member 2
5l0m A 86 A 146
A redox-regulated disulphide may form within Nuclear receptor subfamily 5 group A member 2 between cysteines 86 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
5l0m
Structure name
hlrh-1 dna binding domain - 12bp oct4 promoter complex
Structure deposition date
2016-07-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
12
% buried
nan
Peptide accession
O00482
Residue number A
86
Residue number B
146
Peptide name
Nuclear receptor subfamily 5 group A member 2
Ligandability
Cysteine 86 of Nuclear receptor subfamily 5 group A member 2
Cysteine 146 of Nuclear receptor subfamily 5 group A member 2
2a66 A 103 A 146
A redox-regulated disulphide may form within Nuclear receptor subfamily 5 group A member 2 between cysteines 103 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
2a66
Structure name
human liver receptor homologue dna-binding domain (hlrh-1 dbd) in complex with dsdna from the hcyp7a1 promoter
Structure deposition date
2005-07-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
8
% buried
90
Peptide accession
O00482
Residue number A
103
Residue number B
146
Peptide name
Nuclear receptor subfamily 5 group A member 2
Ligandability
Cysteine 103 of Nuclear receptor subfamily 5 group A member 2
Cysteine 146 of Nuclear receptor subfamily 5 group A member 2
5l0m A 86 A 106
A redox-regulated disulphide may form within Nuclear receptor subfamily 5 group A member 2 between cysteines 86 and 106. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
5l0m
Structure name
hlrh-1 dna binding domain - 12bp oct4 promoter complex
Structure deposition date
2016-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
23
% buried
nan
Peptide accession
O00482
Residue number A
86
Residue number B
106
Peptide name
Nuclear receptor subfamily 5 group A member 2
Ligandability
Cysteine 86 of Nuclear receptor subfamily 5 group A member 2
Cysteine 106 of Nuclear receptor subfamily 5 group A member 2
5l0m A 89 A 146
A redox-regulated disulphide may form within Nuclear receptor subfamily 5 group A member 2 between cysteines 89 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
5l0m
Structure name
hlrh-1 dna binding domain - 12bp oct4 promoter complex
Structure deposition date
2016-07-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
12
% buried
79
Peptide accession
O00482
Residue number A
89
Residue number B
146
Peptide name
Nuclear receptor subfamily 5 group A member 2
Ligandability
Cysteine 89 of Nuclear receptor subfamily 5 group A member 2
Cysteine 146 of Nuclear receptor subfamily 5 group A member 2
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