Fatty-acid amide hydrolase 1
Intramolecular
Cysteine 551 and cysteine 561
Cysteine 196 and cysteine 400
Cysteine 144 and cysteine 269
Cysteine 144 and cysteine 168
Cysteine 113 and cysteine 196
Cysteine 196 and cysteine 249
Cysteine 113 and cysteine 249
Cysteine 252 and cysteine 551
4do3 B 551 B 561
A redox-regulated disulphide may form within Fatty-acid amide hydrolase 1 between cysteines 551 and 561. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
4do3
Structure name
structure of faah with a non-steroidal anti-inflammatory drug
Structure deposition date
2012-02-09
Thiol separation (Å)
6
Half-sphere exposure sum ?
94
Minimum pKa ?
13
% buried
100
Peptide accession
P97612
Residue number A
551
Residue number B
561
Peptide name
Fatty-acid amide hydrolase 1
Ligandability
Cysteine 551 of Fatty-acid amide hydrolase 1
Cysteine 561 of Fatty-acid amide hydrolase 1
4j5p B 196 B 400
A redox-regulated disulphide may form within Fatty-acid amide hydrolase 1 between cysteines 196 and 400. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
4j5p
Structure name
crystal structure of a covalently bound alpha-ketoheterocycle inhibitor (phenhexyl/oxadiazole/pyridine) to a humanized variant of fatty acid amide hydrolase
Structure deposition date
2013-02-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
96
Minimum pKa ?
12
% buried
100
Peptide accession
P97612
Residue number A
196
Residue number B
400
Peptide name
Fatty-acid amide hydrolase 1
Ligandability
Cysteine 196 of Fatty-acid amide hydrolase 1
Cysteine 400 of Fatty-acid amide hydrolase 1
2vya A 144 A 269
A redox-regulated disulphide may form within Fatty-acid amide hydrolase 1 between cysteines 144 and 269. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
2vya
Structure name
crystal structure of fatty acid amide hydrolase conjugated with the drug-like inhibitor pf-750
Structure deposition date
2008-07-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P97612
Residue number A
144
Residue number B
269
Peptide name
Fatty-acid amide hydrolase 1
Ligandability
Cysteine 144 of Fatty-acid amide hydrolase 1
Cysteine 269 of Fatty-acid amide hydrolase 1
3qk5 B 144 B 168
A redox-regulated disulphide may form within Fatty-acid amide hydrolase 1 between cysteines 144 and 168. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
3qk5
Structure name
crystal structure of fatty acid amide hydrolase with small molecule inhibitor
Structure deposition date
2011-01-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
100
Peptide accession
P97612
Residue number A
144
Residue number B
168
Peptide name
Fatty-acid amide hydrolase 1
Ligandability
Cysteine 144 of Fatty-acid amide hydrolase 1
Cysteine 168 of Fatty-acid amide hydrolase 1
1mt5 P 113 P 196
A redox-regulated disulphide may form within Fatty-acid amide hydrolase 1 between cysteines 113 and 196. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
1mt5
Structure name
crystal structure of fatty acid amide hydrolase
Structure deposition date
2002-09-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
107
Minimum pKa ?
12
% buried
100
Peptide accession
P97612
Residue number A
113
Residue number B
196
Peptide name
Fatty-acid amide hydrolase 1
Ligandability
Cysteine 113 of Fatty-acid amide hydrolase 1
Cysteine 196 of Fatty-acid amide hydrolase 1
1mt5 I 196 I 249
A redox-regulated disulphide may form within Fatty-acid amide hydrolase 1 between cysteines 196 and 249. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
1mt5
Structure name
crystal structure of fatty acid amide hydrolase
Structure deposition date
2002-09-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
105
Minimum pKa ?
12
% buried
100
Peptide accession
P97612
Residue number A
196
Residue number B
249
Peptide name
Fatty-acid amide hydrolase 1
Ligandability
Cysteine 196 of Fatty-acid amide hydrolase 1
Cysteine 249 of Fatty-acid amide hydrolase 1
1mt5 G 113 G 249
A redox-regulated disulphide may form within Fatty-acid amide hydrolase 1 between cysteines 113 and 249. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
26
PDB code
1mt5
Structure name
crystal structure of fatty acid amide hydrolase
Structure deposition date
2002-09-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
103
Minimum pKa ?
12
% buried
100
Peptide accession
P97612
Residue number A
113
Residue number B
249
Peptide name
Fatty-acid amide hydrolase 1
Ligandability
Cysteine 113 of Fatty-acid amide hydrolase 1
Cysteine 249 of Fatty-acid amide hydrolase 1
1mt5 B 252 B 551
A redox-regulated disulphide may form within Fatty-acid amide hydrolase 1 between cysteines 252 and 551. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
23
PDB code
1mt5
Structure name
crystal structure of fatty acid amide hydrolase
Structure deposition date
2002-09-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
100
Minimum pKa ?
14
% buried
100
Peptide accession
P97612
Residue number A
252
Residue number B
551
Peptide name
Fatty-acid amide hydrolase 1
Ligandability
Cysteine 252 of Fatty-acid amide hydrolase 1
Cysteine 551 of Fatty-acid amide hydrolase 1
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