ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Krev interaction trapped protein 1

Intermolecular
Cysteine 320 of Sorting nexin-17 and cysteine 228 L
Intramolecular
Cysteine 329 and cysteine 346
A redox-regulated disulphide may form between cysteine 320 of Sorting nexin-17 and cysteine 228 of Krev interaction trapped protein 1.

Details

Redox score ?
80
PDB code
4tkn
Structure name
structure of the snx17 ferm domain bound to the second npxf motif of krit1
Structure deposition date
2014-05-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
8
% buried
24
Peptide A name
Sorting nexin-17
Peptide B name
Krev interaction trapped protein 1
Peptide A accession
Q15036
Peptide B accession
O00522
Peptide A residue number
320
Peptide B residue number
228

Ligandability

Cysteine 320 of Sorting nexin-17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 228 of Krev interaction trapped protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Krev interaction trapped protein 1 between cysteines 329 and 346. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
5d68
Structure name
crystal structure of krit1 ard-ferm
Structure deposition date
2015-08-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
99
Peptide accession
O00522
Residue number A
329
Residue number B
346
Peptide name
Krev interaction trapped protein 1

Ligandability

Cysteine 329 of Krev interaction trapped protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 346 of Krev interaction trapped protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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