ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ATP-dependent RNA helicase DDX3X

Intramolecular
Cysteine 298 and cysteine 317 L
Cysteine 317 and cysteine 341 L
A redox-regulated disulphide may form within ATP-dependent RNA helicase DDX3X between cysteines 298 and 317.

Details

Redox score ?
69
PDB code
7liu
Structure name
ddx3x bound to atp analog and remodeled rna:dna hybrid
Structure deposition date
2021-01-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
8
% buried
88
Peptide accession
O00571
Residue number A
298
Residue number B
317
Peptide name
ATP-dependent RNA helicase DDX3X

Ligandability

Cysteine 298 of ATP-dependent RNA helicase DDX3X

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 317 of ATP-dependent RNA helicase DDX3X

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent RNA helicase DDX3X between cysteines 317 and 341. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
5e7i
Structure name
crystal structure of the active catalytic core of the human dead-box protein ddx3
Structure deposition date
2015-10-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
100
Peptide accession
O00571
Residue number A
317
Residue number B
341
Peptide name
ATP-dependent RNA helicase DDX3X

Ligandability

Cysteine 317 of ATP-dependent RNA helicase DDX3X

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 341 of ATP-dependent RNA helicase DDX3X

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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