ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ribonuclease T2

Intramolecular
Cysteine 184 and cysteine 241
Cysteine 48 and cysteine 55
Cysteine 202 and cysteine 213
Cysteine 75 and cysteine 121
A redox-regulated disulphide may form within Ribonuclease T2 between cysteines 184 and 241.

Details

Redox score ?
87
PDB code
3t0o
Structure name
crystal structure analysis of human rnase t2
Structure deposition date
2011-07-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00584
Residue number A
184
Residue number B
241
Peptide name
Ribonuclease T2

Ligandability

Cysteine 184 of Ribonuclease T2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 241 of Ribonuclease T2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease T2 between cysteines 48 and 55.

Details

Redox score ?
87
PDB code
3t0o
Structure name
crystal structure analysis of human rnase t2
Structure deposition date
2011-07-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00584
Residue number A
48
Residue number B
55
Peptide name
Ribonuclease T2

Ligandability

Cysteine 48 of Ribonuclease T2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 55 of Ribonuclease T2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease T2 between cysteines 202 and 213.

Details

Redox score ?
84
PDB code
3t0o
Structure name
crystal structure analysis of human rnase t2
Structure deposition date
2011-07-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00584
Residue number A
202
Residue number B
213
Peptide name
Ribonuclease T2

Ligandability

Cysteine 202 of Ribonuclease T2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 213 of Ribonuclease T2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease T2 between cysteines 75 and 121.

Details

Redox score ?
82
PDB code
3t0o
Structure name
crystal structure analysis of human rnase t2
Structure deposition date
2011-07-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
O00584
Residue number A
75
Residue number B
121
Peptide name
Ribonuclease T2

Ligandability

Cysteine 75 of Ribonuclease T2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of Ribonuclease T2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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