ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Beta-1,3-N-acetylglucosaminyltransferase manic fringe

Intramolecular
Cysteine 110 and cysteine 121
Cysteine 306 and cysteine 315
Cysteine 139 and cysteine 202
A redox-regulated disulphide may form within Beta-1,3-N-acetylglucosaminyltransferase manic fringe between cysteines 110 and 121.

Details

Redox score ?
88
PDB code
2j0a
Structure name
structure of the catalytic domain of mouse manic fringe
Structure deposition date
2006-08-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
O09008
Residue number A
110
Residue number B
121
Peptide name
Beta-1,3-N-acetylglucosaminyltransferase manic fringe

Ligandability

Cysteine 110 of Beta-1,3-N-acetylglucosaminyltransferase manic fringe

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of Beta-1,3-N-acetylglucosaminyltransferase manic fringe

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-1,3-N-acetylglucosaminyltransferase manic fringe between cysteines 306 and 315.

Details

Redox score ?
87
PDB code
2j0a
Structure name
structure of the catalytic domain of mouse manic fringe
Structure deposition date
2006-08-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
O09008
Residue number A
306
Residue number B
315
Peptide name
Beta-1,3-N-acetylglucosaminyltransferase manic fringe

Ligandability

Cysteine 306 of Beta-1,3-N-acetylglucosaminyltransferase manic fringe

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 315 of Beta-1,3-N-acetylglucosaminyltransferase manic fringe

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-1,3-N-acetylglucosaminyltransferase manic fringe between cysteines 139 and 202.

Details

Redox score ?
78
PDB code
2j0a
Structure name
structure of the catalytic domain of mouse manic fringe
Structure deposition date
2006-08-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
O09008
Residue number A
139
Residue number B
202
Peptide name
Beta-1,3-N-acetylglucosaminyltransferase manic fringe

Ligandability

Cysteine 139 of Beta-1,3-N-acetylglucosaminyltransferase manic fringe

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of Beta-1,3-N-acetylglucosaminyltransferase manic fringe

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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