ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Importin subunit alpha-3

Intermolecular
Cysteine 248 and cysteine 248
Intramolecular
Cysteine 417 and cysteine 456
A redox-regulated disulphide may form between two units of Importin subunit alpha-3 at cysteines 248 and 248. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6wx8
Structure name
sox2 bound to importin-alpha 3
Structure deposition date
2020-05-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
94
Peptide A name
Importin subunit alpha-3
Peptide B name
Importin subunit alpha-3
Peptide A accession
O00629
Peptide B accession
O00629
Peptide A residue number
248
Peptide B residue number
248

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Importin subunit alpha-3 between cysteines 417 and 456.

Details

Redox score ?
76
PDB code
5tbk
Structure name
crystal structure of human importin a3 bound to rcc1
Structure deposition date
2016-09-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
6
% buried
60
Peptide accession
O00629
Residue number A
417
Residue number B
456
Peptide name
Importin subunit alpha-3

Ligandability

Cysteine 417 of Importin subunit alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 456 of Importin subunit alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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