ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cyclin-dependent kinase 2-associated protein 1

Intermolecular
Cysteine 105 and cysteine 105
A redox-regulated disulphide may form between two units of Cyclin-dependent kinase 2-associated protein 1 at cysteines 105 and 105 (105 and 305 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
2kw6
Structure name
solution nmr structure of cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1; oral cancer suppressor deleted in oral cancer 1, doc-1) from h
Structure deposition date
2010-03-31
Thiol separation (Å)
6
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
51
Peptide A name
Cyclin-dependent kinase 2-associated protein 1
Peptide B name
Cyclin-dependent kinase 2-associated protein 1
Peptide A accession
O14519
Peptide B accession
O14519
Peptide A residue number
105
Peptide B residue number
105

Ligandability

Cysteine 105 of Cyclin-dependent kinase 2-associated protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Cyclin-dependent kinase 2-associated protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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