ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Intramolecular
Cysteine 88 and cysteine 150
A redox-regulated disulphide may form within Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial between cysteines 88 and 150 (65 and 127 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
3ae1
Structure name
crystal structure of porcine heart mitochondrial complex ii bound with n-phenyl-2-(trifluoromethyl)-benzamide
Structure deposition date
2010-02-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
21
Peptide accession
A5GZW8
Residue number A
88
Residue number B
150
Peptide name
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Ligandability

Cysteine 88 of Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 150 of Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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